Effect of glucose metabolism on postoperative olfactory improvement in patients with chronic sinusitis and multivariate analysis
Objective To investigate the effect of glucose metabolism on postoperative improvement of olfactory function in patients with chronic rhinosinustitis(CRS).Methods A total of 100 patients with CRS who underwent endoscopic sinus surgery(ESS)in the Department of Otorhinolaryngology of our hospital from January 2019 to December 2021 were retrospectively included.According to the improvement of postoperative olfactory dysfunction,they were divided into olfactory improvement group and olfactory non-improvement group.The glucose metabolism status(including normal blood glucose,prediabetes and diabetes)and clinical data were analyzed.Univariate analysis was used to screen the factors affecting olfactory improvement and logistic multivariate analysis was performed.The distribution of glucose metabolism status was compared between the two groups.Results Among the 100 patients with CRS,the olfactory function was not improved in 22 cases(22.00%)6 months after operation,and the olfactory function was improved in 78 cases(78.00%).Multivariate logistic analysis showed that allergic diseases,smoking history,fasting blood glucose(FBG),oral glucose tolerance test(OGTT),homeostasis model assessment of insulin resistance(HOMA-IR)and eosinophil percentage were independent factors influencing the improvement of olfactory function in patients with CRS after endoscopic ESS sinus surgery(P<0.05).The detection rate of IFG in the non-improved olfactory function group was 45.45%higher than that in the improved olfactory function group(15.38%),and the difference was statistically significant(P<0.05).Conclusions The detection rate of IFG in CRS patients with unimproved olfactory function after surgery is higher.Allergic diseases,smoking history,FBG,OGTT,HOMA-IR,and percentage of eosinophils were independent influencing factors for the improvement of olfactory function in CRS patients after nasal ESSendoscopy.
glucose metabolism statuschronic rhinosi-nusitisendoscopic sinus surgeryolfactory function
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