Study on mechanism of Yiqixuanhua Formula regulating serum IgE and nasal mucosa IL-10 expression in mice with allergic rhinitis
Background Allergic rhinitis is a common allergic disease,the severity of clinical symptoms is closely related to the level of IgE in serum.The IL-10 family of cytokines plays a crucial role in the pathogenesis of allergic rhinitis by inhibiting excessive inflammatory response,upregulating innate immunity,and promoting tissue repair mechanisms.The traditional Chinese medicine Yiqixuanhua Formula has a good clinical effect on treating allergic rhinitis.Objective Taking OVA induced allergic rhinitis animal model as the research object,this study elucidates the mechanism of Yiqixuanhua Formula affecting the secretion of IL-10 in nasal mucosa and inhibiting allergic rhinitis.Methods A total of 24 mice were randomly divided into a blank control group of 6 and an allergic rhinitis model group of 18.Mouse model of allergic rhinitis was established.The model group was divided into three groups,each receiving physiological saline,Yiqixuanhua Formula and loratadine intervention.The behavioral scores of mice were observed.Serum IgE content and nasal mucosal IL-10 content of mice were detected through ELISA analysis.Result Yiqixuanhua Formula can effectively reduce the clinical manifestations of allergic rhinitis mice(P<0.05),reduce the IgE content in the peripheral blood of allergic rhinitis mice(P<0.05),and increase the IL-10 content in nasal mucosa tissue(P<0.05).Conclusion Yiqixuanhua Formula has the effect of treating allergic rhinitis by regulating serum IgE content and nasal mucosal IL-10 secretion.
万方数据
维普
