Resting-State Functional Magnetic Resonance Imaging of Tinnitus in Patients with Chronic Kidney Essence Deficiency Syndrome
Objective To observe the central characteristics of resting functional magnetic resonance imaging (fMRI) in tinnitus patients with chronic kidney essence deficiency syndrome,analyze its correlation with clinical features,and explore the possible neuroimaging mechanism and significance. Methods From August 2020 to December 2022,92 tinnitus patients with chronic kidney essence deficiency syndrome and 91 healthy volunteers recruited in the same period were enrolled in our department to complete rest fMRI scanning and clinical information collection. The different brain regions of the two groups were calculated by low frequency amplitude (ALFF) analysis,and the ALFF values were extracted and correlated with the clinical characteristics of the patients. In addition,the functional connections (FC) between the differential brain regions and the whole brain were calculated. Results Compared with the healthy control group,the ALFF values of bilateral anterior cuneate lobe and left posterior cingulate gyrus increased,while those of right precentral gyrus and right postcentral gyrus decreased in the patient group. Correlation analysis showed that the THI score of the left posterior cingulate gyrus was positively correlated with the ALFF value of the left posterior cingulate gyrus (r=0.641,P<0.001),and negatively correlated with the SAS score of the right precentral gyrus (r=0.601,P<0.001). The brain regions with significant changes in low frequency amplitudes were taken as regions of interest to analyze the functional connections of the whole brain. the results showed that the functional connections of the left middle temporal gyrus the left middle occipital gyrus and the left postcentral gyrus were weakened. Conclusion The functional connection intensity of multiple brain regions in tinnitus patients with chronic kidney essence deficiency syndrome is abnormal,involving default network,limbic system,auditory network,visual network and other brain regions. The left posterior cingulate gyrus and the right precentral gyrus may be neuroimaging indicators for evaluating the severity of tinnitus and negative emotion of tinnitus respectively.
tinnitusrs-fMRIsyndrome of deficiency of kidney essenceALFFFC
万方数据
维普
