Effect of Xiangsha Liujunzi Decoction combined with Entecavir on T cell subsets in patients with decompensation period of hepatitis B cirrhosis
Objective:To investigate the effects of Xiangsha Liujunzi Decoction combined with Entecavir on fi-broblast growth factor(FGF)-9,FGF-21 and cellular immunity in patients with decompensation period of hepatitis B cirrhosis.Methods:One hundred and twenty patients with decompensated hepatitis B cirrhosis who received treatment in our hospital from May 2020 to December 2022 were selected for this study.They were divided into control group and study group by random number table method.The control group was treated with Entecavir,and the study group was treated with Xiangsha Liujunzi Decoction on the basis of the control group.The therapeu-tic effect and T cell subsets before and after treatment were compared.Results:The total effective rate of the study group was higher than that of the control group(P＞0.05).After treatment,the scores of Traditional Chi-nese Medicine symptoms in both the control group and the study group were significantly reduced compared with before treatment,and the reduction in the study group was greater than that in the control group(P＜0.05).Af-ter treatment,hyaluronic acid(HA),laminin,LN,procollagen Ⅲ(PC Ⅲ)and Ⅳ collagen(Ⅳ-C)decreased signifi-cantly compared with that before treatment,and pre-albumin(PA),albumin(ALB)and serum cholinesterase(CHE)increased significantly.The improvement of these indexes in the study group was higher than those in the control group(P＜0.05).After treatment,the serum FGF-9 level was significantly decreased and FGF-21 level was significantly increased,T cell subsets CD3+,CD4+,CD4+/CD8+were significantly increased in both groups,while CD8+was significantly decreased,and the improvement degree of the study group was better than that of the control group(P＜0.05).No serious adverse reactions were observed in the two groups,which were tolerated by the patients.Conclusion:Xiangsha Liujunzi Decoction combined with conventional Entecavir can sig-nificantly improve the symptoms of patients with hepatitis B cirrhosis,promote the recovery of liver function indi-cators,and also significantly improve the levels of FGF-9 and FGF-21,delay the progress of disease,and enhance the cellular immune function of the body,which is worthy of clinical application.
decompensation period of hepatitis B cirrhosisXiangsha Liujunzi DecoctionEntecavirfibroblast growth factorcellular immune function
万方数据
维普
