目的:观察胃复春配伍三七粉治疗慢性糜烂性胃炎的有效性及安全性。方法:选取2022年7月-2023年7月符合慢性糜烂性胃炎诊断标准的108例患者为研究对象，按随机数字表法分组:对照组(雷贝拉唑肠溶片，54例)和观察组(胃复春胶囊+三七粉，54例)，均治疗4周。主要指标为4周后胃镜下黏膜糜烂程度改善临床总有效率;次要指标为中医症状积分和总有效率，血清血管内皮生长因子(vascular endothlial growth factor，VEGF)、前列腺素 E2(prostaglandin E2，PGE2)、超氧物歧化酶(superoxide dismutase，SOD)及丙二醛(malondial-dehyde，MDA)表达水平，胃肠道生活质量指数(gastrointestinal quality of life index，GIQLI)积分及安全性指标。结果:治疗后，观察组患者胃镜下黏膜糜烂程度改善总有效率(94。44％)显著高于对照组(77。78％);观察组中医症状积分显著低于对照组(P＜0。05)，中医临床总有效率显著高于对照组(P＜0。05);观察组SOD、VEGF、PGE2显著高于对照组(P＜0。05)，MDA显著低于对照组(P＜0。05)。治疗后及停药1个月后随访，观察组GIQLI积分均显著低于对照组(P＜0。05)。两组均未见明显不良反应及并发症发生。结论:胃复春配伍三七粉能提高慢性糜烂性胃炎治疗的内镜下及中医临床有效率，降低中医症状积分;促进胃黏膜再生，增加微血管循环，提高抗氧化能力，提升患者的胃肠道生活质量，改善患者的主观感受和生活工作能力。
Observation of the efficacy of Weifuchun capsule with Sanqi powder on chronic erosive gastritis and its effects of SOD,MDA,VEGF and PGE2 expressions
Objective:To observe the efficacy and safety of Weifuchun capsule with Sanqi powder in the treat-ment of chronic erosive gastritis.Methods:One hundred and eight patients eligible for chronic erosive gastritis in the department of gastroenterology from July,2022 to July,2023 were selected and divided into two groups ac-cording to the random number table method:54 cases in the control group treated with rabeprazole,and 54 cases in the observation group treated with Weifuchun capsule and Sanqi powder.Both groups were treated for four weeks.The primary indicator was the total clinical efficiency of improvement in the degree of mucosal erosion un-der gastroscopy after four weeks.Secondary indicators were Traditional Chinese Medicine symptom score and total effective rate,serum SOD,MDA,VEGF,PGE2 expression levels,and gastrointestinal quality of life index(GIQ-LI).The safety indexes were adverse events.Results:After treatment,the total effective rate of improvement in the degree of gastroscopic mucosal erosion in the observation group(94.44％)was significantly higher than that in the control group(77.78％);the Traditional Chinese Medicine symptom scores were significantly lower than that in the control group(P＜0.05).SOD,VEGF,PGE2 were significantly higher in the observation group than in the control group after treatment(P＜0.05);MDA was significantly lower than in the control group(P＜0.05).The GIQLI scores in the observation group were significantly lower than those in the control group after treatment and at the follow-up after one month of drug discontinuation(P＜0.05).No significant adverse reactions and com-plications were observed in both groups.Conclusion:Weifuchun capsule with Sanqi powder can improve the endo-scopic and Traditional Chinese Medicine clinical efficiency of erosive gastritis treatment and reduce the Traditional Chinese Medicine symptom scores;promote regeneration of gastric mucosa and increase microvascular circulation(implied by VEGF and PGE2)and enhance antioxidant capacity(implied by SOD and MDA);and improve pa-tients' GIQLI,their subjective feelings,and their ability to live and work.
万方数据
维普
