Clinical observation of Xiangchai Shuyu Decoction combined with probiotics in treating constipation irritable bowel syndrome with liver depression and Qi stagnation syndrome
Objective:To observe the clinical effect of Xiangchai Shuyu Decoction combined with constipation-predominant irritable bowel syndrome(IBS-C)with liver depression and Qi stagnation.Methods:Ninety patients with IBS-C with liver depression and Qi stagnation syndrome were randomly divided into the control group and the treatment group,45 patients in each group.The control group was treated with Bifidobacterium triple live bacteria enteric-coated capsules,while the treatment group was treated with Xiangchai Shuyu Decoction on the basis of the control group.After 4 weeks'continuous treatment,the improvement of Traditional Chinese Medicine(TCM)syndrome score in the two groups was observed before and after 4 weeks'treatment.The mental and psychological status of patients was evaluated by Hamilton anxiety scale(HAMA)and Hamilton depression scale(HAMD),and the changes of intestinal flora were detected.The clinical effective rate and incidence of untoward effects were compared between the two groups.Results:The TCM syndromes of all patients in both groups had improved after treatment,and the improvement effects of abdominal pain,abdominal distension,defecation frequency,stool characteristics,frequent belching,chest tightness and hypochondriac pain in the treatment group was superior to that of the control group(P＜0.05),while there was no difference in defecation status between the two groups(P＞0.05).The scores of HAMA and HAMD in both groups were decreased in different degrees,and the score in the treatment group was more significantly decreased(P＜0.05).The levels of intestinal bifidobacteria and lac-tobacilli in both groups increased,while the levels of enterobacteriaceae decreased.The levels of bifidobacteria and lactobacilli in the treatment group were higher than those in the control group,while the levels of enterobacteriace-ae were lower than those in the control group(P＜0.05).Comparing the occurrence rate of untoward effects of two groups,there was no obvious difference(P＞0.05).The aggregate effective rate of the treatment group was 92.86％,up from 73.81％in the control group(P＜0.05).Conclusion:Xiangchai Shuyu Decoction combined with probiotics has a significant clinical effect on IBS-C with liver-Qi stagnation syndrome,and can effectively re-lieve bad mood,optimize intestinal flora,and safe.
Xiangchai Shuyu Decoctionconstipation-predominant irritable bowel syndromesyndrome of liver depression and Qi stagnationprobioticsintestinal flora
万方数据
维普
