Clinical study on the effect of"clearing turbid regulating liver and invigorating spleen"method on indicators of hepatitis B virus liver cirrhosis
Objective:To observe the clinical efficacy of the method of resolving turbid,regulating liver and in-vigorating spleen in the treatment of hepatitis B virus liver cirrhosis(HBV-LC).Methods:The random number ta-ble method was used to divide 112 cases of HBV-LC patients into the"removing turbidity and regulating liver"treatment group(referred to as the treatment group)and the control group,with 56 cases each.The control group was given antiviral treatment with entecavir dispersible tablets,while the treatment group received additional treatment with Huazhuo Tiaogan Jianpi Tang on the basis of the control group.Both groups were treated for three months.After treatment,the clinical efficacy,total score of TCM symptoms,liver function index,four serum i-tems of liver fibrosis,Fibrotouch liver hardness,and the level of inflammatory factors in peripheral blood were compared between the two groups.Results:After three months,the treatment group's clinical curative effect of total effective rate was higher than the control group,and TCM symptoms in the treatment group total score was lower than the control group(P＜0.05).The levels of glutamic oxaloacetic transaminase(AST),glutamic pyruvic transaminase(ALT),gamma-glutamyltransferase(GGT),total bilirubin(TBIL),laminin(LN),hyaluronic acid(HA),type Ⅲ procollagen amino terminal peptide(PCⅢ NP),type Ⅳ collagen(C-Ⅳ),liver elasticity index,in-terleukin 17A(IL-17A)and interleukin 6(IL-6)decreased after treatment in both groups(P＜0.05).And all indi-cators of the treatment group were lower than those in the control group.Interleukin-10(IL-10)levels increased after treatment in both groups and were higher in the treatment group than in the control group.The differences were statistically significant(P＜0.05).Conclusion:The principle of"resolving turbid,regulating liver and invig-orating spleen"in the treatment of HBV-related liver cirrhosis can obtain a better clinical effect,effectively im-prove the total score of TCM symptoms,liver function and liver fibrosis index,reduce the level of inflammatory factors,and delay the progression of liver cirrhosis.
hepatitis B virus liver cirrhosisclearing turbid regulating liver and invigorating spleeninflam-matory factors
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