Preliminary study on the efficacy and related mechanisms of Geqin Xiaokui Formula combined with mesalazine in the treatment of ulcerative colitis
Objective:To explore the clinical efficacy of Geqin Xiaokui Formula combined with mesalazine in the treatment of ulcerative colitis(UC).Methods:Ninety patients with UC admitted to our hospital from June 2019 to December 2022 were randomly divided into an observation group and a control group,with 45 patients in each group.The control group received mesalazine enteric-coated tablets,0.5 g each time,three times a day;The observation group was treated with Geqin Xiaokui Formula for 8 weeks.The traditional Chinese medicine(TCM)syndrome score,Baron score,colon histopathological score,Sutherland disease activity index score before and af-ter treatment were compared,and the levels of serum D-lactate,diamine oxidase(DAO),endotoxin(ETX),intes-tinal mucosal forkhead box protein A2(FOXA2)mRNA,and hypoxia-inducible factor-1α(HIF-1α)mRNA,Mi-croRNA-31-3p(miR-31-3p)expression were compared,and the total effective rate and adverse reaction rate of the two groups were compared.Results:After treatment,the TCM syndrome score,Baron score,colonic histopatho-logical score,and Sutherland disease activity index score of the observation group were lower than those of the control group(P＜0.01).The levels of D-lactic acid,DAO,and ETX in serum were lower than those of the con-trol group(P＜0.01),and the expression of FOXA2 mRNA in mucosal tissue was higher than that of the control group(P＜0.01).The expression of HIF-1α mRNA and miR-31-3p of the two groups was lower than that of the control group(P＜0.01),and the total effective rate of treatment was higher than that of the control group(P＜0.05).There was no statistically significant difference in the rate of adverse reactions between the two groups(P＞0.05).Conclusion:Geqin Xiaokui Formula combined with mesalazine can effectively improve traditional Chinese medicine syndromes,protect intestinal mucosal function,promote intestinal mucosal healing,and have a signifi-cant effect and safety in the treatment of UC.The mechanism may be related to the expression of regulation of mu-cosal organization FOXA2 mRNA and HIF-1α MRNA and miR-31-3p.
ulcerative colitistraditional Chinese medicineGeqin Xiaokui Formulamesalazinemechanism
万方数据
维普
