Effect of removing blood stasis and clearing intestine method on active ulcerative colitis of left colon type
Objective:To observe the therapeutic effect of removing blood stasis and clearing intestines method on left colon type active ulcerative colitis.Methods:One hundred patients with active ulcerative colitis of left colon type admitted to our hospital from January 2022 to December 2022 were selected as study cases.They were divided into an experimental group and a control group according to the computer random number grouping method.The control group was treated with Mesalazine enteric-coated tablets,and the experimental group was treated with re-moving blood stasis and clearing intestines method+retention enema based on the control group.After 8 weeks of treatment,the clinical efficiency and induced remission rate of the two groups were evaluated.The changes in TCM symptom scores and inflammatory bowel disease quality of life questionnaire(IBDQ)scores of the two groups before and after treatment were compared.Blood coagulation parameters[prothrombin time(PT),activa-ted partial thrombin time(APTT),fibrinogen(FIB),mean platelet volume(MPV)and serum inflammatory cyto-kines tumor necrosis factor α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8)and interleukin-10(IL-10)]were measured to observe the changes of inflammation and blood hypercoagulability.Observe the changes in routine se-rological indicators[white blood cell(WBC),hemoglobin(HGB)and plasma albumin(ALB)]levels before and af-ter treatment in two groups.Results:Compared with before treatment,the scores of traditional Chinese medicine symptoms in the experimental group and control group were significantly reduced,and the IBDQ scale score was significantly improved(P＜0.05).PT and APTT were significantly prolonged,MPV was significantly increased,and FIB was significantly reduced(P＜0.05).The content of TNF-α,IL-6 and IL-8 significantly decreased,while the content of IL-10 significantly increased(P＜0.05).The WBC level significantly decreased(P＜0.05)and there was no statistically significant difference in HGB and ALB levels compared to before treatment(P＞0.05).After treatment,the total clinical effective rate and induced remission rate of the experimental group were significantly better than those of the control group(P＜0.05).The experimental group showed better improvement in tradition-al Chinese medicine symptoms,quality of life scores,coagulation-related parameters,inflammatory factors,and routine serological indicators than the control group(P＜0.05).Conclusion:The method of removing blood stasis and clearing intestines has a good effect and safety on left colon-type active ulcerative colitis,which can alleviate the clinical symptoms of patients and improve the quality of life.Its mechanism may be related to regulating the hypercoagulability of blood and reducing the expression of inflammatory factors.
ulcerative colitisremoving blood stasis and clearing intestines methodtraditional Chinese medi-cine enemainflammatory cytokines
万方数据
维普
