Ulcerative colitis(UC)is a kind of unexplained idiopathic and persistent inflammatory bowel dis-ease characterized by abdominal pain,mucous stool,bloody stool,and tenesmus.Chronic inflammation is a major feature of the colon in patients with UC.Traditional Chinese medicine believes that the etiology of UC is insepara-ble from heat pathogens.Heat-clearing Chinese Medicine has many advantages such as definite curative effects and mild side effects in the treatment of UC,so it is widely used in clinic.In the past,based on the characteristics of chronic inflammation and easy carcinogenesis of UC,many related signaling pathways have been studied,and the regulation of"inflammatory-cancer transformation"is also a new clinical method for the treatment of UC.In re-cent years,there has been more and more research on the mechanism of Heat-clearing Chinese Medicine on UC.The purpose of this paper is to summarize the six signaling pathways of UC treatment:TLR4/MyD88/NF-κB sig-naling pathway,PI3K/AKT signaling pathway,MAPK signaling pathway,IL-6/JAK2/STAT3 signaling path-way,Nrf2/NQO1 signaling pathway and NLRP3/Caspase-1 signaling pathway,in order to provide new ideas for clinical researchers in the treatment of UC with traditional Chinese medicine.
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