首页|益气解毒凉血法联合西医治疗细菌性肝脓肿临床疗效观察

益气解毒凉血法联合西医治疗细菌性肝脓肿临床疗效观察

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目的:观察益气解毒凉血法联合西医治疗细菌性肝脓肿的临床疗效。方法:选取首都医科大学附属北京地坛医院2020年1月-2023年10月收治的61例细菌性肝脓肿住院患者,按1 ∶2比例随机分为中西医组和对照组,对照组(41例)给予西医治疗,中西医组(20例)在对照组基础上联合益气解毒凉血法中药汤剂治疗,疗程2~4周,比较两组的临床疗效。结果:两组患者经治疗后均体温正常、肝脓肿好转出院,无死亡病例。中西医组在第1周时肝脓肿直径缩小的患者比例为85。0%(17/20),高于对照组的58。5%(24/41),差异有统计学意义(P<0。05);中西医组抗菌药物累计消耗量(cDDDs)为23。48±15。07,对照组为33。52±21。12,两组差异有统计学意义(P<0。05)。两组患者在治疗第2周时,白细胞、中性粒细胞计数、中性粒细胞/淋巴细胞比值(NLR)、降钙素原、C反应蛋白均较治疗前明显下降,差异有统计学意义(均P<0。05);治疗第3周时与对照组比较,中西医组淋巴细胞计数上升、NLR明显下降,均差异有统计学意义(均P<0。05);两组在治疗第1周时丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、γ-谷氨酰基转移酶(GGT)较治疗前明显下降,治疗第2周时中西医组ALT、AST、GGT明显降低,与同时间点对照组比较均差异有统计学意义(均P<0。05)。结论:益气解毒凉血法联合西医治疗细菌性肝脓肿可更快地促进肝脓肿吸收,减轻机体和肝脏炎症,并可减少抗生素的使用。
Observation on the clinical effect of Yiqi Jiedu Liangxue combined with Western Medicine in treating pyogenic liver abscess
Objective:To observe the clinical effect of Yiqi Jiedu Liangxue combined with Western Medicine in the treatment of pyogenic liver abscess.Methods:A total of 61 inpatients with pyogenic liver abscess admitted to Beijing Ditan Hospital from January 2020 to October 2023 were selected.According to 1:2,the patients were randomly divided into two groups,the integrated Chinese and Western Medicine group and the control group.For-ty-one cases in the control group were given Western Medicine treatment,and 20 cases in the integrated Chinese and Western Medicine group were treated with Traditional Chinese Medicine decoction for Yiqi Jiedu Liangxue on the basis of the control group.The course of treatment was 2-4 weeks,and the clinical efficacy of the two groups was compared.Results:The temperature was normal and liver abscess was improved of both groups after treat-ment.No death cases were reported.In the first week,the proportion of patients with reduced liver abscess diam-eter in the integrated Chinese and Western Medicine group was 85.0%(17/20),which was better than that in the control group 58.5%(24/41)(P<0.05).The antibiotic cumulative defined daily doses(cDDDs)in the integrated Chinese and Western Medicine group was 23.48±15.07,which was better than that in the control group(33.52± 21.12)(P<0.05).After the second week of treatment,WBC,Neu,NLR,PCT and CRP in both groups were significantly decreased compared with those before treatment(all P<0.05);at the third week,compared with the control group,lymphocyte count in the integrated Chinese and Western Medicine group was increased and NLR was significantly decreased(all P<0.05).At the first week of treatment,ALT,AST and GGT in the two groups were significantly decreased compared with that before treatment,and at the second week of treatment,ALT,AST and GGT in the combined Chinese and Western Medicine group were significantly decreased,compared with the control group at the same time point(all P<0.05).Conclusion:Yiqi Jiedu Liangxue decoction combined with Western Medicine can accelerate the absorption of liver abscess,promote the reduction of body and liver inflamma-tion,and reduce the use of antibiotics.

pyogenic liver abscessYiqi Jiedu Liangxue methodintegrated Traditional Chinese and Western Medicinepercutaneous catheter drainage

王晓静、时克、王宪波

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首都医科大学附属北京地坛医院中西医结合中心(北京,100015)

细菌性肝脓肿 益气解毒凉血法 中西医结合疗法 经皮穿刺引流术

国家中医药局高水平中医药重点学科建设项目首都卫生发展科研专项批准项目

zyyzdxk-20230052024-1-2173

2024

中国中西医结合消化杂志
华中科技大学同济医学院,中国中西医结合学会消化系统疾病专业委员会,中华中医药学会脾胃病专业委员会

中国中西医结合消化杂志

CSTPCD
影响因子:1.363
ISSN:1671-038X
年,卷(期):2024.32(3)
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