Impacts of modified Zuojin pill combined with ear acupoint therapy on symptom improvement and the levels of GAS and MTL in patients with gastroesophageal reflux disease
Impacts of modified Zuojin pill combined with ear acupoint therapy on symptom improvement and the levels of GAS and MTL in patients with gastroesophageal reflux disease
Objective:To analyze the impacts of modified Zuojin pill combined with ear acupoint therapy on symptom improvement and the levels of gastrin(GAS)and motilin(MTL)in patients with gastroesophageal reflux disease.Methods:Eighty outpatient and inpatient patients from our hospital from November 2021 to October 2022 were collected as the research subjects.They were randomly separated into an experimental group and a western medicine group according to the statistical analysis system(SAS)random program,with 40 patients in each group;the western medicine group was treated with esomeprazole magnesium enteric coated tablets,while the ex-perimental group was treated with self-designed modified Zuojin pill and ear acupoint therapy;after 8 weeks of treatment,the clinical efficacy,incidence of adverse reactions,and recurrence rate of both groups were observed and recorded,the Traditional Chinese Medicine(TCM)scores,gastroesophageal reflux disease diagnostic ques-tionnaire(GerdQ)and self-rating anxiety scale(SAS)scores,the levels of GAS and MTL were compared between the two groups.Results:The total clinical effective rate in the experimental group was 90.00％,which was higher than 72.50％in the western medicine group(P＜0.05);after treatment,the TCM syndrome score of both groups obviously decreased(P＜0.05),and the experimental group was lower than the western medicine group(P＜0.05);after treatment,the GerdQ and SAS scores in both groups were obviously lower than before treat-ment(P＜0.05),and the experimental group were lower than the western medicine group(P＜0.05);after treat-ment,the levels of GAS and MTL in both groups were obviously higher than before treatment(P＜0.05),and the experimental group were higher than the western medicine group(P＜0.05);there was no difference in the inci-dence of adverse reactions such as dry mouth,diarrhea,nausea,constipation,and dizziness between the two groups(P＞0.05);after treatment,the recurrence rate in the experimental group was obviously lower than that in the western medicine group(P＜0.05).Conclusion:The combination of modified Zuojin pill and ear acupoint ther-apy can improve the treatment efficiency of patients with gastroesophageal reflux disease,reduce the recurrence rate,and improve the levels of GAS,MTL,and quality of life of the patients.
维普
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