Impacts of modified Zuojin pill combined with ear acupoint therapy on symptom improvement and the levels of GAS and MTL in patients with gastroesophageal reflux disease
Objective:To analyze the impacts of modified Zuojin pill combined with ear acupoint therapy on symptom improvement and the levels of gastrin(GAS)and motilin(MTL)in patients with gastroesophageal reflux disease.Methods:Eighty outpatient and inpatient patients from our hospital from November 2021 to October 2022 were collected as the research subjects.They were randomly separated into an experimental group and a western medicine group according to the statistical analysis system(SAS)random program,with 40 patients in each group;the western medicine group was treated with esomeprazole magnesium enteric coated tablets,while the ex-perimental group was treated with self-designed modified Zuojin pill and ear acupoint therapy;after 8 weeks of treatment,the clinical efficacy,incidence of adverse reactions,and recurrence rate of both groups were observed and recorded,the Traditional Chinese Medicine(TCM)scores,gastroesophageal reflux disease diagnostic ques-tionnaire(GerdQ)and self-rating anxiety scale(SAS)scores,the levels of GAS and MTL were compared between the two groups.Results:The total clinical effective rate in the experimental group was 90.00％,which was higher than 72.50％in the western medicine group(P＜0.05);after treatment,the TCM syndrome score of both groups obviously decreased(P＜0.05),and the experimental group was lower than the western medicine group(P＜0.05);after treatment,the GerdQ and SAS scores in both groups were obviously lower than before treat-ment(P＜0.05),and the experimental group were lower than the western medicine group(P＜0.05);after treat-ment,the levels of GAS and MTL in both groups were obviously higher than before treatment(P＜0.05),and the experimental group were higher than the western medicine group(P＜0.05);there was no difference in the inci-dence of adverse reactions such as dry mouth,diarrhea,nausea,constipation,and dizziness between the two groups(P＞0.05);after treatment,the recurrence rate in the experimental group was obviously lower than that in the western medicine group(P＜0.05).Conclusion:The combination of modified Zuojin pill and ear acupoint ther-apy can improve the treatment efficiency of patients with gastroesophageal reflux disease,reduce the recurrence rate,and improve the levels of GAS,MTL,and quality of life of the patients.
万方数据
维普
