Effects of Shenling Baizhu Granule combined with pivilium bromide on immune function,intestinal flora and brain intestinal peptide in irritable bowel syndrome with predominant diarrhea
Objective:To investigate the effects of Shenling Baizhu Granule combined with pivectium bromide on intestinal flora and serum nerve growth factor(NGF)and brain-derived neurotrophic factor(BDNF)in patients of irritable bowel syndrome with predominant diarrhea(IBS-D).Methods:A total of 168 IBS-D patients admitted to our hospital from February 2018 to September 2021 were randomly divided into observation group and control group,with 84 cases in each group.The control group was treated with pivemonium bromide,and the observation group was treated with Shenling Baizhu Granule on the basis of the control group.The efficacy,immune function,intestinal flora,brain intestinal peptide and adverse reactions were compared between the two groups.Results:The effective rate of observation group(90.48％)was higher than that of control group(73.81％),the difference was statistically significant(P=0.042).After treatment,the levels of immunoglobulin A(IgA),immunoglobulin M(IgM),CD3+,CD4+and CD4+/CD8+in the observation group were significantly higher than those in the con-trol group(t=7.955,8.371,9.712,7.684 and 4.817,P＜0.001).After treatment,the colony number levels of bifidobacterial,lactobacillus and bacteroidetes in the observation group were significantly higher than those in the control group(t=4.256,5.328 and 4.007,P＜0.001),while the colony number levels of enterobacteria and en-terococcus were significantly lower than those in the control group(t=-4.764 and-8.083,P＜0.001).The levels of NGF,BDNF,5-hydroxytryptamine(5-HT)and substance P(SP)in the observation group were signifi-cantly lower than those in the control group after treatment(t=-9.639,-13.529,-17.321 and-16.902,P＜0.001).Hierarchical linear regression showed that Shenmai injection increased the exposure risk of bifidobac-teria,Lactobacillus and Bacteroidetes by 21％,32％ and 36％ in male patients,and decreased the exposure risk of enterobacteria and enterococcus by 33％and 25％.Shenmai injection increased the exposure risk of bifidobacteri-al,Lactobacillus and Bacteroidetes by 23％,29％ and 32％,and decreased the exposure risk of enterobacteria and enterococcus by 37％and 22％.There was no significant interaction effect between different genders and groups(P=0.376,0.283,0.197,0.356 and 0.241).Conclusion:Shenling Baizhu Granule can improve the cura-tive effect of IBS-D patients,enhance immune function,regulate intestinal flora,and reduce serum levels of NGF and BDNF,which has good clinical application value.
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