Clinical observation of Jianpi Qus hi Jiedu Tongluo Decoction combined with remedial quadruple therapy in the treatment of refractory Helicobacter pylori infection
Objective:To observe the clinical efficacy and safety of Jianpi Qushi Jiedu Tongluo Decoction com-bined with remedial quadruple therapy in the treatment of refractory Helicobacter pylori infection(RHPI).Meth-ods:Patients diagnosed with RHPI were randomly divided into the treatment group and the control group in the 1∶2 ratio,with 23 patients in the treatment group and 46 patients in the control group.The remedial quad-ruple therapy was used in the control group for 14 days;the treatment group was treated with remedial quadruple therapy combined with Jianpi Qushi Jiedu Tongluo Decoction,with a course of remedial quadruple therapy for 10 days(taken on the 1st-10th day after inclusion),and a course of Traditional Chinese Medicine(TCM)for 14 days(taken on the 11th-24th day after inclusion).To observe the eradication rate of Helicobacter pylori(H.pylori)8 weeks after drug discontinuation,the TCM symptom score and TCM efficacy after drug discontinuation and 8 weeks after drug discontinuation,and the incidence of adverse reactions during the treatment period.Results:The H.pylori eradication rate of the treatment group was 91.3％(21/23),which was better than that of the control group(82.6％,38/46)(P＞0.05).After stopping the medication,the treatment group was better than the control group in improving loose stools and total symptom scores;after stopping the medication for 8 weeks,the treat-ment group was better than the control group in improving epigastric distension,epigastric pain,belching,acid reflux and heartburn,dry mouth and bitter taste,loose stools and total symptom scores(P＜0.05);as for the ef-ficacy of TCM,the efficacy of the treatment group was better after stopping the medication and 8 weeks after stopping the medication(P＜0.05).In terms of adverse reactions,the incidence rate of adverse reactions in the treatment group was 4.3％lower than the rate of adverse reactions in the control group,which was 17.4％(P＞0.05).Conclusion:Jianpi Qushi Jiedu Tongluo Decoction combined with remedial quadruple therapy is an effective regimen for the treatment of RHPI,which reduces the amount of antibiotics while maintaining the H.pylori e-radication rate comparable to that of the remedial quadruple therapy,and significantly improves the clinical symp-toms.
万方数据
维普
