Clinical observation of Jianpi Qus hi Jiedu Tongluo Decoction combined with remedial quadruple therapy in the treatment of refractory Helicobacter pylori infection
Clinical observation of Jianpi Qus hi Jiedu Tongluo Decoction combined with remedial quadruple therapy in the treatment of refractory Helicobacter pylori infection
Objective:To observe the clinical efficacy and safety of Jianpi Qushi Jiedu Tongluo Decoction com-bined with remedial quadruple therapy in the treatment of refractory Helicobacter pylori infection(RHPI).Meth-ods:Patients diagnosed with RHPI were randomly divided into the treatment group and the control group in the 1∶2 ratio,with 23 patients in the treatment group and 46 patients in the control group.The remedial quad-ruple therapy was used in the control group for 14 days;the treatment group was treated with remedial quadruple therapy combined with Jianpi Qushi Jiedu Tongluo Decoction,with a course of remedial quadruple therapy for 10 days(taken on the 1st-10th day after inclusion),and a course of Traditional Chinese Medicine(TCM)for 14 days(taken on the 11th-24th day after inclusion).To observe the eradication rate of Helicobacter pylori(H.pylori)8 weeks after drug discontinuation,the TCM symptom score and TCM efficacy after drug discontinuation and 8 weeks after drug discontinuation,and the incidence of adverse reactions during the treatment period.Results:The H.pylori eradication rate of the treatment group was 91.3％(21/23),which was better than that of the control group(82.6％,38/46)(P＞0.05).After stopping the medication,the treatment group was better than the control group in improving loose stools and total symptom scores;after stopping the medication for 8 weeks,the treat-ment group was better than the control group in improving epigastric distension,epigastric pain,belching,acid reflux and heartburn,dry mouth and bitter taste,loose stools and total symptom scores(P＜0.05);as for the ef-ficacy of TCM,the efficacy of the treatment group was better after stopping the medication and 8 weeks after stopping the medication(P＜0.05).In terms of adverse reactions,the incidence rate of adverse reactions in the treatment group was 4.3％lower than the rate of adverse reactions in the control group,which was 17.4％(P＞0.05).Conclusion:Jianpi Qushi Jiedu Tongluo Decoction combined with remedial quadruple therapy is an effective regimen for the treatment of RHPI,which reduces the amount of antibiotics while maintaining the H.pylori e-radication rate comparable to that of the remedial quadruple therapy,and significantly improves the clinical symp-toms.
维普
万方数据