Correlation of non-alcoholic fatty liver disease patients of different Traditional Chinese Medicine syndrome with Th17/Treg levels in the peripheral blood
Objective:To analyze the correlation between non-alcoholic fatty liver disease(NAFLD)patients of different Traditional Chinese Medicine(TCM)syndromes with Th17/Treg in peripheral blood.Methods:One hundred NAFLD patients who visited the clinic from January 2022 to April 2023 were collected and divided into five groups based on TCM syndrome,and another 15 healthy volunteers were selected as the control group.The liver function,blood lipid,blood glucose,BMI,controlled attenuation parameter(CAP)value,levels of Th17/Treg and cytokines in peripheral blood were detected respectively,and the correlation between the disease index and levels of Th17/Treg was analyzed by the Pearson test.Results:The results of correlation analysis showed that the levels of liver function(ALT,AST,GGT,ALP),lipids(TC,TG),FBG,BMI,CAP,Th17/Treg,IL-17,and IL-22 in patients with NAFLD showed a significant positive correlation with Th17(P＜0.05),while a signifi-cant negative correlation was observed with Treg(P＜0.05).Compared with the control group,NAFLD patients showed significantly higher levels of liver function(ALT,AST,GGT,ALP),TC,TG,FBG,BMI,CAP,Th17,IL-17 and IL-22,and lower levels of IL-10 and Treg(P＜0.05).Comparison of various indicators in NAFLD patients with different TCM syndromes.AST,ALT,GGT,ALP,TC,TG,BMI,FBG,CAP,IL-17,IL-22,Th17 levels and Th17/Treg ratio are sorted by syndrome type.From high to low,they are the damp-heat accumulation syndrome,the phlegm stasis mutual accumulation syndrome,dampness turbidity internal cessation syndrome,spleen kidney deficiency syndrome and liver depression and spleen deficiency syndrome.However,the ranking of Treg levels showed the opposite trend in the comparison of different TCM syndromes.Conclusion:There is a certain correlation between the TCM syndromes of NAFLD patients and the balance of Th17/Treg,with the highest level of Th17 in patients with the dampness heat accumulation syndrome.
non-alcoholic fatty liver diseaseTraditional Chinese Medicine syndromeshelper T cell 17reg-ulatory T cell
万方数据
维普
