Study on Traditional Chinese Medicine syndromes of patients with gastroesophageal reflux disease based on multivariate statistical methods
Objective:To explore the Traditional Chinese Medicine(TCM)diagnostic features of the syndrome of stagnated heat and yin injury in gastroesophageal reflux disease(GERD),by using the multivariate statistical methods,so as to provide some objective basis for the formulation of diagnostic criteria.Methods:The TCM syn-drome data of 402 GERD patients were collected to develop a clinical symptom information collection table,collect relevant information,and establish a TCM syndrome database which were randomly divided into the training sam-ple group and verification sample group.A quantitative diagnosis model was established based on the training sam-ple group data,the binary logistic stepwise regression analysis was used to screen related factors,conditional probability conversion formulas were used to establish a score table for related factors,the CART decision tree is used to prune the diagnostic model,ROC curves was drawn to select the best diagnostic threshold,the sensitivity,specificity,accuracy,and positive likelihood ratio were calculated respectively according to the diagnostic test eval-uation principles,the quantitative diagnostic model was analyzed and evaluated,and finally the validation sample group data was used to complete the scientific attribute evaluation of the model.Results:A total of 28 clinical fea-tures were extracted.After stepwise regression analysis,16 relevant factors were finally obtained,8 positively correlated factors,8 negatively correlated factors;then we got six TCM syndrome elements by the CART,which screening out two judgment rules;after quantitative scoring.The ROC curve,sensitivity,specificity,accuracy,and positive likelihood ratio of retrospective test and prospective test were 0.993,95.0％,97.0％,96.3％,32.0 and 0.949,87.5％,92.7％,90.1％,12.0 respectively.The model had good scientificity and practicality.Con-clusion:Based on Logistic regression analysis,ROC curve and CART decision tree algorithm,the diagnostic mod-el of gastroesophageal reflux heat-yin injury syndrome can be effectively established,which provides an objective basis for clinical syndrome differentiation and treatment.
gastroesophageal reflux diseasesyndrome of stagnated heat and yin injurylogistic linear regres-sionCART
万方数据
维普
