Research progress of mesenchymal stem cell in treating anal fistula in Crohn's disease
Crohn's disease(CD)is a leaping full-layer inflammatory bowel disease involving the whole diges-tive tract.Anal fistula is one of the common clinical manifestations CD,with a clinical incidence of 28％-43％.The treatment of CD anal fistula needs to be combined with the actual situation of the patient to select an individu-alized treatment plan,including appropriate drug types and surgical methods.Currently,there is no gold standard treatment plan with a high success rate,and the clinical recurrence rate is high.Mesenchymal stem cells(MSC)are pluripotent stem cells that have the ability to self-renew and differentiate into multiple cell types and are widely used in the field of regenerative medicine.MSC therapy is a promising new treatment option for patients with CD.Compared with traditional treatments,MSC showed higher efficiency in inducing and maintaining fistula closure,and had a strong immunomodulatory effect and was minimally invasive.Especially for patients with complex fistu-las that are intolerant to conventional treatment.Based on the latest research reports at home and abroad,this ar-ticle reviews the research progress of MSC in treating anal fistula in CD.
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