Key issues in the"inflammation-cancer"transition of atrophic gastritis and research strategies for prevention and treatment with traditional Chinese medicine
Key issues in the"inflammation-cancer"transition of atrophic gastritis and research strategies for prevention and treatment with traditional Chinese medicine
Gastric carcinoma presents a formidable public health challenge,significantly imperiling the life quality and longevity of the populace within China.The strategic surveillance and efficacious intervention targeting populations at elevated risk for gastric cancer can markedly diminish the prevalence of this disease.In particular,atrophic gastritis and its associated precancerous lesions,as pivotal precursors in the oncogenesis of gastric carci-noma,are essential for the proactive management and preventative measures against this disease.Recent scholarly endeavors have posited the hypothesis that the spasmolytic polypeptide-expressing metaplasia(SPEM)might re-present a prospective cellular source for intestinal metaplasia and dysplasia,thus offering fresh perspectives on the molecular mechanisms underpinning the inflammation-to-carcinoma transition in atrophic gastritis.This discourse systematically examines the avant-garde queries concerning atrophic gastritis to gastric carcinoma continuum,ad-vocating for the investigation of SPEM as a significant and viable target for secondary prophylaxis research in gas-tric adenocarcinoma.Furthermore,it addresses the prevailing challenges within the realm of traditional Chinese medicinal research related to atrophic gastritis and its precancerous stages.Through proposing recommendations and strategies,this paper aims to catalyze the development of an integrated Chinese and Western medicine para-digm for the secondary prevention and management of gastric cancer,thereby providing a reference for the ad-vancement of this integrative healthcare strategy.
关键词
萎缩性胃炎/胃癌前病变/中医药/防治/研究策略
Key words
atrophic gastritis/precancerous lesions of gastric cancer/traditional Chinese medicine/preven-tion and treatment/research strategies
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