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溃疡性结肠炎"炎-癌"转化的中医药防治策略

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溃疡性结肠炎相关性结直肠癌(CAC)是由溃疡性结肠炎(UC)反复发作所致。UC病程缠绵,反复发作,证候虚实转换,湿热羁留,化生邪毒是UC"炎-癌"转化的关键病机。因此,构建中医药防治UC"炎-癌"转化策略具有重要意义。为此我们提出:重视慢病管理,实施全程干预;把握病机变化,紧扣关键环节;注意病证结合,实现精准干预;阐明作用机制,助力疗效提高的防治策略,以期为有效阻断UC"炎-癌"转化提供参考。
The strategy of prevention and treatment of"inflammation-cancer"transformation in ulcerative colitis using traditional Chinese medicine
Ulcerative colitis(UC)associated colorectal cancer(CAC)is caused by recurrent episodes of this disease.The key pathogenesis of UC's transformation from inflammation to cancer is the lingering and recurrent course of the disease,the transformation of syndromes from deficiency to excess,the retention of dampness and heat,and the transformation of pathogenic toxins.Therefore,it is important to construct a traditional Chinese medicine(TCM)strategy for the prevention and treatment of UCs"inflammation-cancer"transformation.We pro-pose to attach the importance of the management of chronic disease,and implement full process intervention;grasp the changes in the pathogenesis,and the key links;pay attention to the combination of disease and syn-drome,and achieve precise intervention;clarify the mechanism of action,and improve the efficacy.It may provide an example for preventing the transformation from UC to cancer.

ulcerative colitisinflammation-cancer transformationprevention and treatment using traditional Chinese medicine

沈洪、邢敬、胡静怡、朱磊

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南京中医药大学附属医院江苏省中医院消化科(南京,210029)

溃疡性结肠炎 "炎-癌"转化 中医药防治

国家中医药局高水平中医药重点学科建设项目国家自然科学基金江苏省中医药科技发展计划重点项目

国中医药人教函202385号82274483ZD202212

2024

中国中西医结合消化杂志
华中科技大学同济医学院,中国中西医结合学会消化系统疾病专业委员会,中华中医药学会脾胃病专业委员会

中国中西医结合消化杂志

CSTPCD
影响因子:1.363
ISSN:1671-038X
年,卷(期):2024.32(5)