Summary and evaluation of animal models for precancerous gastric lesions
The development of precancerous lesions in the stomach marks a pivotal juncture for the secondary prevention of gastric cancer.The establishment of animal models for these precancerous conditions,characterized by simplicity of manipulation,robust controllability,and high stability,constitutes the cornerstone for advancing our understanding of the disease's etiology and for pioneering therapeutic interventions.This paper synthesizes and categorizes prevalent methodologies employed in the generation of such animal models,including Helicobacter spe-cies infection,induction by chemical carcinogens,multifactorial combination inductions,and gene-editing tech-niques.Additionally,it offers a concise review of the distinct features,advantages,and limitations of each model,alongside a discussion on the critical considerations for evaluating these animal models.The insights provided aim to serve as a comprehensive reference for the conceptualization and utilization of animal models in the study of pre-cancerous gastric lesions.
万方数据
维普
