首页|非酒精性脂肪性肝病更名:从代谢功能障碍相关脂肪肝异质性到"同病异治"

非酒精性脂肪性肝病更名:从代谢功能障碍相关脂肪肝异质性到"同病异治"

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关于非酒精性脂肪性肝病(NAFLD)更名为代谢功能障碍相关脂肪肝(MAFLD/MASLD)近两年来争议不断,期间大数据研究结果证明了 NAFLD的时代局限性.重新审视命名法,可以正确认识NAFLD关键致病因素、了解其异质性及不同临床表型.目前NAFLD药物疗法临床应答率不高,通过分析其异质性,结合中医"同病异治"理论为临床诊断、研究、治疗NAFLD提供参考.
Renaming non-alcoholic fatty liver disease:from metabolic dysfunction-associated fatty liver heterogeneity to"different treatment for the same disease"
The renaming of non-alcoholic fatty liver disease(NAFLD)to metabolic dysfunction-associated fatty/steatotic liver disease(MAFLD/MAFLD)has been controversial for the last two years,during which the re-sults of big data studies have proved the age-old limitations of NAFLD.Revisiting the nomenclature will allow for a proper understanding of the key causative factors of NAFLD,and an appreciation of its heterogeneity and differ-ent clinical phenotypes.The clinical response rate of NAFLD drug therapy is not high.By analyzing its heteroge-neity and combining it with the theory of"different treatment for the same disease"in traditional Chinese medi-cine,we can provide references for clinical diagnosis,research,and treatment of NAFLD.

non-alcoholic fatty liver diseasemetabolic fatty liver diseaseheterogeneityhomoeopathy

刘嘉玲、孙劲晖

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北京中医药大学东直门医院(北京,100700)

非酒精性脂肪性肝病 代谢性脂肪肝疾病 异质性 同病异治

国家自然科学基金

81573969

2024

中国中西医结合消化杂志
华中科技大学同济医学院,中国中西医结合学会消化系统疾病专业委员会,中华中医药学会脾胃病专业委员会

中国中西医结合消化杂志

CSTPCD
影响因子:1.363
ISSN:1671-038X
年,卷(期):2024.32(5)