目的:探讨粪便钙卫蛋白(fecal calprotectin,FC)联合中性粒细胞/淋巴细胞比值(neutrophil-to-lym-phocyte ratio,NLR)在腺瘤性结肠息肉患者中的诊断价值.方法:选择南京市浦口区中医院脾胃科2022年1月-2023年3月诊治的100例腺瘤性结肠息肉患者(腺瘤性息肉组)及100例增生性结肠息肉患者(增生性息肉组)为研究对象,采用单因素及多因素分析影响腺瘤性结肠息肉患者的危险因素,并绘制受试者工作特征(receiv-er operating characteristic,ROC)曲线,评估FC对腺瘤性结肠息肉的诊断价值.结果:与增生性息肉组比较,腺瘤性息肉组患者的 FC 及 NLR 水平均显著增高[88.90(69.71,104.33)μg/g vs 56.28(45.83,66.84)µg/g;2.36(1.78,2.73)vs 1.56(1.33,1.73)],差异有统计学意义(P＜0.001).二元 logistic 回归分析发现,FC 及 NLR 均是影响腺瘤性结肠息肉患者的独立危险因素(FC:OR=6.533,95％CI:1.075～1.141,P＜0.001;NLR:OR=1.173,95％CI:1.722～8.105,P=0.001).ROC曲线分析显示,FC、NLR、FC联合NLR指标对腺瘤性结肠息肉患者均具有一定的诊断价值,以FC联合NLR的诊断效能最佳(AUC=0.902,95％CI:0.862～0.942,P＜0.001),最佳截断值为0.267,灵敏度为94％,特异度为67％.结论:FC联合NLR对腺瘤性结肠息肉患者具有良好的诊断价值.
Diagnostic value of fecal calprotectin combined with neutrophil-to-lymphocyte ratio in adenomatous colonic polyps
Objective:To investigate the diagnostic value of fecal calprotectin(FC)combined with neutrophil to-lymphocyte ratio(NLR)in adenomatous colonic polyps.Methods:One hundred patients with adenomatous co-lonic polyps admitted to Department of Spleen and Stomach,Nanjing Pukou District Hospital of Traditional Chi-nese Medicine were enrolled as the adenomatous colonic polyp group,and 100 patients with hyperplastic colonic polyps were enrolled as hyperplastic colonic polyps group.Univariate and multivariate analyses were used to ana-lyze the risk factors of patients with adenomatous colonic polyps.The receiver operating characteristic(ROC)curve was plotted to evaluate the diagnostic efficacy of FC in adenomatous colonic polyps.Results:Compared to the hyperplastic colonic polyps group,the FC and NLR were significantly higher in the adenomatous colonic polyp group[88.90(69.71,104.33)μg/g vs 56.28(45.83,66.84)μg/g;2.36(1.78,2.73)vs 1.56(1.33,1.73);both P＜0.001].Binary logistic regression analysis showed that FC and NLR were independent risk factors of the pa-tients with adenomatous colonic polyp[FC:odds ratio(OR)=6.533,95％CI:1.075-1.141,P＜0.001;NLR:OR=1.173,95％CI:1.722-8.105,P=0.001].ROC curve analysis showed that FC combined with NLR could be used for clinical diagnosis of patients with adenomatous colonic polyp(AUC=0.902,95％CI:0.862-0.942,P＜0.001),best truncation value is 0.267,sensitivity is 94％and specificity is 67％.Conclusion:FC com-bined with NLR is helpful for clinical diagnosis of patients with adenomatous colonic polyps.
colonic polypsfecal calprotectinneutrophil-to-lymphocyte ratio
NETL
NSTL
万方数据
