The therapeutic effect of Shugan Tongjiang compound on patients with gastroesophageal reflux disease
Objective:To study the maintenance effect of the Shugan Tongjiang compound on gastro-esophage-al reflux disease(GERD)patients after standardized proton pump inhibitors(PPIs)treatment.Methods:A total of 103 GERD patients in compliance with the inclusion and exclusion criteria,were randomly divided into two groups according to the visiting orders,54 patients in the treatment group were treated with formula granule of Shugan Tongjiang compound plus PPIs Simulator,and 49 patients in placebo group were treated with placebo plus PPIs(® Pazolazole Sodium),all courses of treatment were 4 weeks.The scores of reflux symptoms,Pittsburgh sleep quality scale(PSQI),Zung self-rating anxiety and depression scale(SDS/SDS),and quality of life scale(SF-36)were compared before and after treatment.Results:Compared with baseline,the symptom scores of esophageal reflux symptoms,such as acid regurgitation,heartburn,food regurgitation,and retrosternal pain,and the total scores after 4 weeks of treatment,were significantly decreased in both groups(P＜0.05),but there was no signif-icant differences between the two groups(P＞0.05).There was no significant difference in PSQI between baseline and 4 weeks after treatment(P＞0.05)in the two groups,and no significant differences(P＞0.05)was found in SAS and SDS either,even if the scores were decreased from baseline after 4 weeks treatment in both groups,and no significant differences were found between the two groups(P＞0.05).In SF-36,the scores of psychological function,social function and general health were significantly improved in the Shugan Tongjiang compound group at 4 weeks after treatment compared with baseline(P＜0.05),but there were no significant differences between the two groups(P＞0.05).Conclusion:The Shugan Tongjiang compound can improve esophageal reflux symp-toms in GERD patients,and its curative effect is equal to that of PPIs.Shugan Tongjiang compound can improve the quality of life in GERD patients,but no significant improvement was found in sleep quality and psychological conditions.
gastro-esophageal reflux diseaseShugan Tongjiang compoundsymptomspsychological condi-tionquality of life
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维普
