The clinical effect of Zengye Decoction in improving substance P,motilin and microtubule associated protein 2 in patients with slow transit Yin deficiency constipation based on"brain-gut axis"
Objective:To investigate the clinical effect of Zengye Decoction based on brain-gut axis theory on serum substance P(SP),motilin(MLT)and microtubule associated protein 2(MAP-2)in patients with slow tran-sit Yin deficiency constipation(STC).Methods:A total of 116 patients with STC admitted to Cangzhou Hospital Of Integrated TCM-WM·Hebei from April 2020 to April 2023 were selected and they divided into control group(n=58)and observation group(n=58)according to random number table method.The control group was treated with conventional western medicine,and the observation group was treated with Zengye decoction based on the theory of brain-gut axis.Both groups were treated for 2 months.The constipation symptom and fecal trait score of the two groups were observed before and after treatment.The expression levels of SP,MTL and MAP-2 were compared between the two groups before and after treatment.The levels of brain intestinal peptide before and af-ter treatment were compared between the two groups.The scores of mental state before and after treatment were compared between the two groups.The scores of TCM symptoms before and after treatment were compared be-tween the two groups.The incidence of adverse reactions was compared between the two groups.Results:Com-pared with before treatment,constipation symptom score,fecal trait score,SP,MTL,MAP-2 expression level,brain-intestinal peptide level,psychological state and TCM syndrome score of the two groups were improved after treatment(P＜0.05).Compared with the control group,the Cleveland constipation score(CCS)of the observation group was significantly decreased after treatment,and the Bristol stool classification score was significantly in-creased(P＜0.05).Compared with the control group,the levels of SP,MTL and the positive rate of MAP-2 in the observation group after treatment were significantly increased(P＜0.05).Compared with the control group,the level of 5-hydroxytryptamine receptor 4(5-HTR4)was significantly increased in the observation group after treatment,and the level of nitric oxide(NO)was significantly decreased(P＜0.05).Compared with the control group,the scores of self-rating Anxiety Scale(SAS)and self-rating Depression Scale(SDS)in the observation group were significantly decreased after treatment(P＜0.05).Compared with the control group,the TCM syn-drome score of the observation group was significantly lower after treatment(P＜0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P＜0.05).Conclusion:Zengye Decoction based on the"brain-gut axis"theory can significantly improve the levels of SP,MTL,MAP-2,constipation,psychological state and TCM syndrome scores in STC patients,and has high safety,which is worthy of clinical wide application.
brain-gut axisZengye Decoctionslow transit constipationserum substance Pmotilinmicro-tubule-associated protein 2
万方数据
