首页|葛根清肠颗粒联合双歧杆菌治疗腹泻型肠易激综合征的临床疗效观察

葛根清肠颗粒联合双歧杆菌治疗腹泻型肠易激综合征的临床疗效观察

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目的:探究葛根清肠颗粒联合双歧杆菌治疗腹泻型肠易激综合征(IBS-D)胃肠湿热兼气滞证的临床效果。方法:随机将96例患者分为对照组与观察组，每组各48例。对照组口服双歧杆菌三联活菌肠溶胶囊4周，观察组患者在此基础上予口服葛根清肠颗粒各服用4周。比较2组的中医证候积分、临床疗效评定、焦虑抑郁评分(SAS、SDS)、5-羟色胺(5-HT)及不良反应。结果:治疗后观察组临床疗效(95。83％)高于对照组(62。50％)，2组中医证候积分、焦虑抑郁评分、5-HT均较治疗前降低，且观察组低于对照组，差异均有统计学意义(P＜0。05)。结论:葛根清肠颗粒联合双歧杆菌治疗IBS-D胃肠湿热兼气滞证的疗效显著，可提高临床治疗有效率，减轻患者临床症状，降低焦虑抑郁程度。
Clinical efficacy of Gegen Qingchang Granule in the treatment of diarrheal irritable bowel syndrome with gastrointestinal damp-heat and Qi stagnation evidence
Objective:To explore the clinical effect of Gegen Qingchang Granule combined with Enterobacteri-um bifidum in diarrheal irritable bowel syndrome(IBS-D)of Gastrointestinal damp-heat with Qi stagnation syn-drome.Methods:Randomly divided the 96 cases into a control group and observation group each 48 cases.The control group took bifidobacterium enteric capsules for 4 weeks,and on this basis,the patients in the observation group were given Gegen Qingchang Granule for 4 weeks.In the two groups,the TCM syndrome score,clinical ef-ficacy evaluation,anxiety and depression score(SAS,SDS),and 5-HT were compared.Results:After treatment,the clinical efficacy of the observation group(95.83％)was higher than that of the control group(62.50％),and the scores of TCM syndromes,anxiety,and depression score,5-HT in the two groups were lower than before and at the same time the group in observation was lower than the control group,statistically significant(P＜0.05).Conclusion:Gegen Qingchang Granule combined with Bifidobacterium has a remarkable curative effect on IBS-D of Gastrointestinal damp-heat with Qi stagnation syndrome,which can improve the clinical effective rate,relieve the clinical symptoms of patients and reduce the degree of anxiety and depression.

diarrheal irritable bowel syndromeGegen Qingchang GranuleBifidobacterium enteric capsulesdiarrhoeagastrointestinal damp-heat with Qi stagnation syndrome

杨建琪、霍永利、杨倩、娄莹莹、佘延芬

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河北中医药大学(石家庄,050091)

河北中医药大学第一附属医院脾胃病科

腹泻型肠易激综合征 葛根清肠颗粒 双歧杆菌三联活菌肠溶胶囊 泄泻 胃肠湿热兼气滞证

国家重点研发计划项目国家重点研发计划"中医药现代化"重点专项第五批全国中医临床优秀人才研修项目国家中医临床研究基地建设项目

2019YFC17121032022YFC3500601国中医药人教函[2022]1号国中医药科技函[2018]131号

2024

10.3969/j.issn.1671-038X.2024.07.11

中国中西医结合消化杂志
华中科技大学同济医学院,中国中西医结合学会消化系统疾病专业委员会,中华中医药学会脾胃病专业委员会

中国中西医结合消化杂志

CSTPCD
影响因子：1.363
ISSN：1671-038X
年,卷(期)：2024.32(7)