Effects of Yunpi Tiaotang prescription on intestinal flora,blood glucose and lipids in type 2 diabetic patients
Objective:To investigate the effect of Yunpi Tiaotang prescription on intestinal flora and blood glu-cose and blood lipids in patients with type 2 diabetes mellitus,so as to analyze the therapeutic effect of Yunpi Tiaotang recipe.Methods:Ninety cases of type 2 diabetes mellitus(spleen deficiency)in our hospital from March 2021 to March 2023 were selected for the study.Randomized numerical table method was divided into study group and control group,45 cases each.The control group was given conventional treatment,and the study group was given Yunpi Tiaotang prescription on the basis of the control group.The changes in intestinal flora,blood sugar index[fasting blood glucose(FBG),2-hours postprandial glucose(2 h PG),glycated hemoglobin A1c(HbA1c)]and blood lipid index[triglycerides(TG),cholesterol(TC),lowdensity lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)]before and after treatment were compared between the two groups,Pearson method was used to analyze the correlation between intestinal flora and blood glucose and lipid indexes,and the therapeutic effect of traditional Chinese medical symptom improvement and the incidence of adverse reactions.Re-sults:The total effective rate of improvement of TCM symptoms in the study group(97.78％)was higher than that in the control group(82.22％)(P＜0.05).After treatment,the numbers of bifidobacterium,Bacteroides and Lactobacillus in the study group were higher than those in the control group,while the numbers of enterobacteri-um and enterococcus were lower than those in the control group(P＜0.05).The levels of FBG,2hPG,HbAic,TC,TG and LDL-C in the study group were lower than those in the control group,and the level of HDL-C was higher than those in the control group after treatment(P＜0.05).Bifidobacterium,Bacteroides and Lactobacillus were negatively correlated with FBG,2hPG,HbAic,TC,TG and LDL-C,and positively correlated with HDL-C(P＜0.05),while Enterobacter and Enterococcus were positively correlated with FBG,2hPG,HbAic,TC,TG and LDL-C,and negatively correlated with HDL-C(P＜0.05).There was no significant difference in the inci-dence of adverse reactions between the two groups(P＞0.05).Conclusion:Yunpi Tiaotang prescription for the treatment of patients with type 2 diabetes mellitus can improve intestinal disordered flora,enhance the effect of blood glucose and lipid control,and improve therapeutic efficacy,with fewer adverse reactions and higher safety.
type 2 diabetes mellitusYunpi Tiaotang prescriptionintestinal florablood sugarblood lipid
万方数据
维普
