Predictive value of four items of inflammation for the severity of ulcerative colitis
Objective:This study will definitively determine the predictive value of inflammatory components,including C-reaction protein(CRP),procalcitonin(PCT),serum amyloid A(SAA),and IL-6,in identifying the severity of ulcerative colitis(UC).Methods:This research recruited UC patients who were hospitalized in the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from December 2020 to December 2023 of these,155 patients with moderate severity were placed in the observation group and 80 patients with mild severity were placed in the control group.Four data sets on inflammation and general patient information were gathered.ROC curves were utilized to analyze the prediction power of the four inflammatory indicators on the severity of UC,and multifactorial logistic regression analysis was employed to investigate the factors influencing UC severity.Results:Leukocyte count,erythrocyte count,fibrinogen(Fib),CRP,IL-6,PCT,and SAA were higher in the ob-servation group than in the control group(P＜0.001),albumin(ALB)was lower in the control group(P＜0.001).The four predictor values for moderate to severe UC were 0.791,0.728,0.781,0.751,and 0.895,re-spectively,according to ROC curve analysis,which also revealed the values for CRP,IL-6,PCT,and SAA.The AUCs of the four combined predictors of moderate to severe UC were higher than those predicted by CRP,IL-6,PCT,and SAA alone,respectively(P＜0.001).Conclusion:CRP,IL-6,PCT,and SAA are the independent factors affecting the severity of UC,and the combination of the four factors has a high value in predicting the severity of UC.
ulcerative colitisC-reaction proteinIL-6serum amyloid Aprocalcitoninpredictive value
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