Meta-analysis of probiotics in the prevention and treatment of chemotherapy-induced diarrhea
Objective:To systematically evaluate the safety and efficacy of probiotics in preventing and treating chemotherapy-induced diarrhea(CID),so as to provide the evidence-based evidence for clinical practice.Methods:Electronic databases,including EMbase,Cochrane Library,PubMed,CNKI,CBM,VIP and Wanfang databases,were retrieved to search for the randomized controlled trial(RCT)of CID among patients with malignant tumors treated with probiotics as of September 31,2023.Later,the RevMan 5.1 statistical software was employed to ex-tract data and assess the quality of the identified literature for meta-analysis.Results:Thirteen RCT involving a total of 1 032 patients were included into the current meta-analysis.Results of this meta-analysis suggested that conventional symptomatic therapy combined with probiotics could significantly reduce the total diarrhea rate in tumor patients(OR=0.33,95％CI:0.21-0.51,P＜0.001)and grade Ⅲ-Ⅳ diarrhea(OR=0.12,95％CI:0.04-0.39,P＜0.001),increase the total effective rate(OR=4.26,95％CI:2.55-7.12,P＜0.001),and shorten the duration of diarrhea(MD=-1.92,95％CI:-1.96--1.88,P＜0.001),with significant differ-ence.But among patients with grade Ⅰ-Ⅱ diarrhea(OR=0.73,95％CI:0.39-1.38,P=0.330),the differ-ence was not statistically significant.Besides,none of the enrolled study had reported adverse reactions.Conclu-sion:Probiotics can prevent and treat CID of tumor patients effectively during chemotherapy,with less adverse e-vents.
probioticschemotherapy-induced diarrheagut microbiotaduration of diarrhea
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