Explore the core pathogenesis of gastric"inflammation-cancer"transformation based on cag pathogenic island
Helicobacter pylori(HP)is a well-established controllable risk factor for gastric cancer.The HP pathogenic island serves as a distinctive physiological marker for type Ⅰ HP strains that are strong producers of pathogenic viruses.It contains genes encoding toxins,adhesion factors,invasion factors,and other virulence fac-tors,which are directly linked to the pathogenic damage and carcinogenic mechanisms of HP on epithelial cells.This paper integrates modern medical research on the"inflammation-cancer"transformation mechanism in the stomach with the theoretical study of Traditional Chinese Medicine(TCM).It posits that the core pathogenesis of TCM in gastric"inflammation-cancer"transformation is characterized by"spleen deficiency,dampness and turbid-ity,and toxic damage with collateral obstruction".The paper discusses the carcinogenic mechanisms of the cag pathogenic island and its associated virulence factors,elucidates the core pathogenesis of TCM,and outlines the diagnostic and treatment principles for gastric"inflammation-cancer"transformation.The aim is to explore diag-nostic and treatment concepts that combine TCM with Western medicine,which could be beneficial in delaying and reversing the cascade process of gastric"inflammation-cancer"transformation.
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