Clinical efficacy analysis of Weipi formula in the treatment of chronic atrophic gastritis
Objective:To investigate the clinical effect of Weipi formula on under the guidance of liver and spleen combined treatment theory.Methods:Sixty-four patients with chronic atrophic gastritis and intestinal met-aplasia diagnosed by gastroscopy from January 2022 to February 2024 were selected as the research subjects,they were divided into the control group and the experimental group according to random number table method,32 ca-ses in each group.The control group was treated with Xiangsha Liujunzi decoction,take 200 mL each morning and evening;the experimental group was treated with Weipi formula,take 200 mL each morning and evening,a treatment course of four weeks,take three courses of treatment.Compared the clinical efficacy,traditional Chi-nese medicine(TCM)syndrome score,histopathological score,pathological efficacy,and gastric function indica-tors between two groups of patients.Results:The total effective rate of the experimental group was 93.75％,sig-nificantly higher than the control group 71.88％(P＜0.05);after treatment,the pathological scores of inflamma-tion activity,mucosal inflammation,glandular atrophy,intestinal metaplasia,and dysplasia in both groups of pa-tients were significantly lower than before treatment(P＜0.05),the scores for stomach pain,bloating,fatigue,loose stools,and nausea were significantly lower than before treatment(P＜0.05);the pathological scores of in-flammation activity,mucosal inflammation,glandular atrophy,intestinal metaplasia,and dysplasia in the experi-mental group were significantly lower than those in the control group(P＜0.05),the scores for stomach pain,bloating,fatigue,loose stools,and nausea were significantly lower than those in the control group(P＜0.05);the pathological total effective rate of the experimental group(84.38％)was significantly higher than that of the con-trol group(65.63％),and the difference was statistically significant(P＜0.05);the levels of gastric function indi-cators pepsinogen Ⅰ(PG Ⅰ)and pepsinogen 11(PGⅡ)in the control group and the experimental group were lower than before treatment,and the level of gastrin 17(G-17)was higher than before treatment(P＜0.05),moreover,the levels of gastric function indicators PG Ⅰ and PG Ⅱ in the experimental group were significantly lower than those in the control group,and the level of G-17 was higher than that in the control group(P＜0.05).The liver and kidney function,blood routine,urine routine,and stool routine of both groups of patients showed no abnor-malities,and no adverse reactions occurred.Conclusion:Weipi formula is effective in the treatment of chronic a-trophic gastritis,improve the pathological state of the stomach,improve the gastric function,and has good safety.
chronic atrophic gastritisliver and spleen combined treatmentWeipi formulaclinical effectgastric function
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