Effect of probiotics on prevention and treatment of Billroth-Ⅰ postoperative complications of gastric ulcer and improvement of gastrointestinal function
Objective:To explore the effect of perioperative use of probiotics on reducing complications and im-proving gastrointestinal function after Billroth-Ⅰ gastric ulcer surgery,the prospective study was performed and provided the reference for clinical treatment.Methods:Seventy-two patients with gastric ulcer treated by Billroth-Ⅰ surgery were selected for prospective study.The patients were randomly divided into the control group and the observation group,and were treated with probiotics during the perioperative period.The patients'general informa-tion,early postoperative complications and late postoperative complications were collected,and the gastrointesti-nal symptom rating scale(GSRS)was obtained before the surgery,one month and one year after surgery.The general data,postoperative blood counts and infection indicators,early postoperative complications and late post-operative complications were compared between the two groups.The scores of gastrointestinal symptoms before operation,one month and one year after operation were compared between and within two groups.Finally,the effect of perioperative use of probiotics on postoperative complications and gastrointestinal function was investiga-ted.Results:Compared with the control group,patients in the observation group showed a significant reduction in blood infection indicators at one day and five days postoperatively(P＜0.05).In terms of early postoperative com-plications,compared with the control group,the observation group had significantly lower abdominal drainage volume at three days after operation,extubation time,first exhaust time,hospitalization time,and infection rate(P＜0.05).There was no significant difference in the incidence of anastomotic leakage between the two groups(P＞0.05),however the incidence of anastomotic leakage in the observation group was less than that in the control group.In terms of long-term postoperative complications,there was no significant difference in the inci-dence of nutritional disorders,delayed gastric emptying,dumping syndrome and recurrence of gastric ulcer be-tween the two groups(P＞0.05).The comparison of GSRS scores within the group showed that the GSRS scores of the two groups at one month and one year after operation were significantly lower than those before operation,and the scores at one month after operation were significantly lower than those at one year after operation(P＜0.001).Comparison of GSRS scores between groups showed that compared with the control group,the GSRS score of the observation group decreased significantly at one month after operation,the difference was statistically significant(P＜0.001),however there was no significant difference between the two groups before operation and one year after operation(P＞0.05).Conclusion:For patients undergoing Billroth-Ⅰ surgery for gastric ulcer,the use of probiotics during the perioperative period can reduce early postoperative complications,accelerate the recov-ery of gastrointestinal function,shorten the length of hospital stay,and improve the patients'life quality.
万方数据
维普
