ERCP联合健脾清胆汤治疗PH1儿童肝移植术后吻合口狭窄合并化脓性胆管炎伴胆汁瘤1例

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中文摘要：原发性1型高草酸尿症(primary hyperoxaluria type 1,PH1)是一种由于肝酶缺乏致草酸盐全身沉积的罕见遗传性疾病,目前一线治疗推荐肝肾联合移植.肝移植术后多并发吻合口狭窄、化脓性胆管炎等胆道并发症,严重影响患者的生存质量.内镜逆行胰胆管造影术是诊断化脓性胆管炎的"金标准",同时能有效解除胆道梗阻,并根据胆汁药敏结果指导抗生素的应用.中医胆为六腑之一,"腑以通为用",我科经验方健脾清胆汤能疏肝健脾、利湿退黄、清热通腑,有助于减轻胆汁淤积,恢复正常排泄,改善胆道炎症.现报道内镜逆行胰胆管造影术联合健脾清胆汤治疗PH1肝肾联合移植术后吻合口狭窄合并化脓性胆管炎伴胆汁瘤患儿1例,以期提高临床医师对该病的认识.

外文标题：ERCP combined with Jianpi Qingdan decoction was used in the treatment of anastomotic stenosis complicated with suppurative cholangitis with biloma in children with PH1 after liver transplantation

外文摘要：Primary hyperoxaluria type 1(PH1)is a rare genetic disorder caused by systemic oxalate deposition due to liver enzyme deficiency,and combined liver-kidney transplantation is currently recommended as first-line treatment.After liver transplantation,biliary complications such as anastomotic stenosis(AS)and suppurative cholangitis(SC)are often complicated,which significantly affects the quality of life of patients.Endoscopic retro-grade cholangiopancreatography(ERCP)is the"gold standard"for the diagnosis of BC,and it is effective in relie-ving biliary obstruction and guiding the use of antibiotics based on bile susceptibility results.Gallbladder is one of the six Fu-organs in Chinese medicine,"the six hollow viscera keeping its unobstructed state",Jianpi Qingdan de-coction can soothe the liver and fortify the spleen,disinhibit dampness and relieve jaundice,clear heat and remove obstruction of Fu-organs,help to reduce cholestasis,restore normal excretion,and improve biliary inflammation.In order to improve the understanding of clinicians about this disease,ERCP combined with Jianpi Qingdan decoc-tion was reported in the treatment of a child with AS complicated with SC with biloma after PH1 liver-kidney transplantation.

外文关键词：

endoscopic retrograde cholangiopancreatographyJianpi Qingdan decoctionprimary hyperoxalu-ria type 1anastomotic stenosissuppurative cholangitisbiloma

作者：

时鑫、李永静、郝立校、龚彪、丛军

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作者单位：

上海中医药大学附属曙光医院消化医学部(上海,201203)

上海中医药大学附属曙光医院传统医学科

关键词：

内镜逆行胰胆管造影术健脾清胆汤原发性1型高草酸尿症吻合口狭窄化脓性胆管炎胆汁瘤

基金：

科技部国家重点研发计划项目科技部国家重点研发计划项目上海市科学技术委员会临床医学领域项目蔡淦全国名中医传承工作室

项目编号：

2018YFC17041002018YFC170410218401971400MZYGZS-2017003

出版年：

2024

DOI：

10.3969/j.issn.1671-038X.2024.09.16

中国中西医结合消化杂志

华中科技大学同济医学院,中国中西医结合学会消化系统疾病专业委员会,中华中医药学会脾胃病专业委员会

中国中西医结合消化杂志

CSTPCD

影响因子：1.363

ISSN：1671-038X

年,卷(期)：2024.32(9)