Role of intestinal microbes in chemotherapy-associated intestinal mucosal injury
Intestinal mucosal inflammation,also known as intestinal mucosal barrier injury,is a common dose responsive toxicity of radiotherapy and chemotherapy.Diarrhea,pain,ulcers and malnutrition are the main clinical features,and water and electrolyte disorders occur in severe cases,which eventually lead to the interruption of chemotherapy and increase cancer mortality.The pathogenesis of chemotherapy related intestinal mucosal injury is diverse,and there is a lack of effective clinical treatment methods.In recent years,an increasing number of stud-ies have confirmed that gut microbiota plays an important role in the occurrence and development of chemotherapy related intestinal mucosal injury.However,the specific mechanism of how intestinal flora regulates chemothera-py-related intestinal mucosal injury remains unclear.Therefore,from the perspective of intestinal flora,this paper describes its regulatory effect on common pathological reactions(inflammation,oxidative stress,intestinal mucosal barrier damage)associated with chemotherapy,and uses intestinal flora as a carrier to explore potential therapeu-tic means,providing important theoretical references for clinical treatment and basic experiments.
intestinal microbesintestinal mucosal injurytraditional Chinese medicinefecal microbiota transplantation
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维普
