Clinical observation of Qingre Huashi Granules in the treatment of ulcerative colitis with damp-heat syndrome:a randomized,prospective,double-blind clinical trial
Objective:To investigate the clinical efficacy of Qingre Huashi Granules in the treatment of ulcera-tive colitis(UC)with damp-heat syndrome.Methods:A total of 120 mild to moderate UC patients with large in-testine damp-heat syndrome were enrolled,and divided into control group and observation group randomly.The control group was treated with Mesalazine,the observation group was treated with Qingre Huashi Granules com-bined with Mesalazine.The treatment period lasted for one month.The clinical efficacy,the Mayo score,the his-tological score under colonoscopy,and blood indexes were recorded and compared between the two groups before and after treatment.Results:The total effective rate of the observation group was 93.33％,which was higher than that of the control group(76.67％)with a statistical significance(P＜0.05).Following treatment,both groups exhibited a decrease in the Mayo score;however,the observation group demonstrated a superior reduction in the Mayo score compared to the control group,and this difference was statistically significant(P＜0.000 1).The histological scores(Geboes index)were significantly decreased in both groups,but the observation group had lower scores than the control group,and this difference was statistically significant(P＜0.001).Indicators of blood test(WBC,Hb、PLT),serum biochemical indexes(ALT,AST,SCr)and inflammatory factors(CRP,ESR)were also compared between the two groups,and the results showed no difference between the two groups(P＞0.05).Conclusion:The therapeutic efficacy of Qingre Huashi Granules combined with mesalazine in the treatment of UC with large intestine damp-heat syndrome is definitive,and they can effectively reduce the degree of intestinal mucosal lesions and exhibit superior clinical effectiveness compared to Mesalazine monotherapy.
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维普
