Effects of Zengye Chengqi Decoction combined with Dumai moxibustion on intestinal mucosal barrier protection,autonomic nerve,gastric electrical activity,serum c-Kit and microRNA-128 in patients with post-stroke defecation obstacles
Objective:lo observe the effects of Zengye Chengqi Decoction combined with Dumai moxibustion on intestinal mucosal barrier protection,autonomic nerve,gastric electrical activity,serum tyrosine kinase recep-tor(c-Kit)and microRNA-128(miR-128)in patients with post-stroke defecation obstacles.Methods:A total of 120 patients with post-stroke defecation obstacles were selected from Qinhuangdao Hospital of Traditional Chinese Medicine from February 2022 to February 2024.According to the random number table method,they were divid-ed into the Western medicine group and the Traditional Chinese Medicine(TCM)and Western medicine treatment group,each consisting of 60 patients.The Western medicine group received conventional Western medical treat-ment,while the TCM and Western medicine treatment group received additional treatment with Zengye Chengqi Decoction combined with Dumai moxibustion.The clinical efficacy of the two groups was compared after treat-ment.TCM syndrome,Constipation Severity Scale(CSS),autonomic Symptom Scale(SCOPA-AUT)and consti-pation Patients Quality of Life Scale(PAC-QOL)were evaluated before and after treatment.The main frequency of gastric electrical activity and the average amplitude of waveform were detected.Serum levels of lipopolysaccha-ride,stem cell factor(SCF),D-lactic acid,c-Kit and miR-128 were determined.Results:The total effective rate was 96.67％in the treatment group of TCM and Western medicine,and 83.33％in the Western medicine group.The total effective rate in the treatment group of TCM and Western medicine was higher than that in the Western medicine group(P＜0.05).The red score of dry stool,red face and hot body,dry mouth and halitosis,abdominal distension and pain,short urine in the treatment group of TCM and Western medicine were lower than those in the Western medicine group(P＜0.05).The scores of PAC-QOL,CSS and SCOPA-AUT in the treatment group of TCM and Western medicine were lower than those in the Western medicine group(P＜0.05).The main frequency and average amplitude of waveforms in the treatment group of TCM and Western medicine were higher than those in the Western medicine group(P＜0.05).The expressions of lipopolysaccharide and D-lactic acid in the treatment group of TCM and Western medicine were lower than those in the Western medicine group(P＜0.05).The ex-pressions of SCF,c-Kit and miR-128 in the treatment group of TCM and Western medicine were higher than those in the Western medicine group(P＜0.05).Conclusion:The combination of Zengye Chengqi Decoction and Dumai moxibustion in the treatment of patients with post-stroke defecation obstacles provides protection for the intestinal mucosal barrier,enhances SCF,c-Kit,and miR-128 levels,improves gastric electrical activity and autonomic nerve function,and ultimately leads to better clinical efficacy and quality of life.
万方数据
维普
