首页|中医药治疗腹泻型肠易激综合征的作用机制及相关信号通路研究进展

中医药治疗腹泻型肠易激综合征的作用机制及相关信号通路研究进展

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肠易激综合征(IBS)是消化系统常见的功能性肠病,严重影响患者的生活,且病情反复。该病发病率逐年增高,西医采取对症治疗,远期疗效差,易出现不良反应。大量研究表明中医药治疗IBS疗效确切。笔者主要从中医药减少内脏高敏反应、改善肠道黏膜、重建肠道微生态、降低肠道炎性因子、改善胃肠动力、调节胆汁酸代谢六个方面进行总结,中医药发挥着多维度治疗IBS的重要作用,笔者以中医药治疗腹泻型IBS的作用机制及相关信号通路为基础,探究中医药治疗该病的科学依据。
Research progress on the mechanism of action and related signaling pathways of Chinese medicine in the treatment of diarrheal irritable bowel syndrome
Irritable bowel syndrome(IBS)is a common functional bowel disease of the digestive system,seri-ously affecting the patient's work and study,and the disease is repeated.The incidence increased year by year,Western medicine takes symptomatic treatment,long-term efficacy is poor,prone to adverse reactions.A large number of studies have shown that Chinese medicine is effective in treating IBS.The author mainly summarizes six aspects of traditional Chinese medicine(TCM),including reducing visceral hypersensitivity,improving intesti-nal mucosa,rebuilding intestinal microecology,reducing intestinal inflammatory factors,improving gastrointesti-nal motivities,and regulating bile acid metabolism.TCM plays an important role in the multidimensional treat-ment of IBS.Based on the mechanism and related signaling pathways of TCM in the treatment of diarrheal IBS,the author concludes.To explore the scientific support of TCM treatment of the disease.

traditional Chinese medicinediarrheal irritable bowel syndromemechanism of actionsignaling path-ways

李梅梅、黄玉卓、马力亚、舒劲

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甘肃中医药大学(兰州,730000)

甘肃省中医院

中医药 腹泻型肠易激综合征 作用机制 信号通路

2024

中国中西医结合消化杂志
华中科技大学同济医学院,中国中西医结合学会消化系统疾病专业委员会,中华中医药学会脾胃病专业委员会

中国中西医结合消化杂志

CSTPCD
影响因子:1.363
ISSN:1671-038X
年,卷(期):2024.32(10)