The case report:Diagnosis and treatment of porto-sinusoidal vascular disease caused by oxaliplatin
Oxaliplatin(OXA)is a third-generation platinum-based anticancer drug,which is widely used in the treatment of colorectal cancer,liver cancer and gastric cancer.However,its use can lead to several side effects,including hepatic microvascular damage.This paper reports a case of non-cirrhotic portal hypertension caused by OXA,which was diagnosed as porto-sinusoidal vascular disease by liver histopathology.The patient was successfully treated with a combination of traditional Chinese medicine and Western medicine,leading to sig-nificant clinical improvement and alleviation of esophageal and gastric varices.In addition,the literature reviewed the characteristics of hepatic microvascular disease caused by OXA.
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