奥沙利铂引起门静脉肝窦血管病诊治1例
The case report:Diagnosis and treatment of porto-sinusoidal vascular disease caused by oxaliplatin
李容容 1李盟 1孙鑫 2邢枫 2刘成海3
作者信息
- 1. 上海中医药大学附属曙光医院肝病研究所(上海,201203)
- 2. 上海中医药大学附属曙光医院肝病研究所(上海,201203);上海市中医临床重点实验室
- 3. 上海中医药大学附属曙光医院肝病研究所(上海,201203);上海市中医临床重点实验室;肝肾疾病病证教育部重点实验室
- 折叠
摘要
奥沙利铂(oxaliplatin,OXA)为第3代铂类抗癌药,广泛应用于中晚期结直肠癌、肝癌及胃癌等的治疗,但可引起肝脏微血管病变等副作用.本文报道1例奥沙利铂引起的非肝硬化门静脉高压患者,经过肝组织病理诊断为门静脉肝窦血管病,并通过中西医结合诊治,患者临床症状与食管胃底静脉曲张得到缓解;此外,文献回顾了 OXA引起门静脉肝窦血管病等肝脏微血管病变的特点.
Abstract
Oxaliplatin(OXA)is a third-generation platinum-based anticancer drug,which is widely used in the treatment of colorectal cancer,liver cancer and gastric cancer.However,its use can lead to several side effects,including hepatic microvascular damage.This paper reports a case of non-cirrhotic portal hypertension caused by OXA,which was diagnosed as porto-sinusoidal vascular disease by liver histopathology.The patient was successfully treated with a combination of traditional Chinese medicine and Western medicine,leading to sig-nificant clinical improvement and alleviation of esophageal and gastric varices.In addition,the literature reviewed the characteristics of hepatic microvascular disease caused by OXA.
关键词
奥沙利铂/门静脉肝窦血管病/肝窦内皮细胞/机制Key words
oxaliplatin/porto-sinusoidal vascular disorder/liver sinusoidal endothelial cell/mechanism引用本文复制引用
出版年
2024
NETL
NSTL
万方数据