Effect of Zusanli injection combined with abdominal acupoint application on gastrointestinal function recovery,immune function and inflammatory state after laparoscopic surgery
Objective:To investigate the clinical effectiveness of combining Zusanli injection with abdominal acupoint application in enhancing gastrointestinal function recovery,immune response,and mitigating inflamma-tory conditions among patients post laparoscopic surgery.Methods:A total of 192 patients undergoing laparoscop-ic procedures at Qinhuangdao Hospital of Traditional Chinese Medicine between January 2021 and January 2024 were enrolled and randomly assigned to four groups(A,B,C,D;n=48 each)by random number table method.Group A received standard postoperative care,while Group B additionally received Zusanli injection,Group C re-ceived abdominal acupoint application,and Group D received both interventions.The treatment duration for all groups was 3 days.The gastrointestinal function(time to first bowel sounds,first defecation,and first flatus),immune function(differentiation cluster[CD]3+,CD4+,CD4+/CD8+),inflammatory state(interleukin-6[IL-6],interleukin-10[IL-10],tumor necrosis factor-α[TNF-α])and the incidence of postoperative vomiting and abdomi-nal distension were compared among the four groups.Results:Groups B,C,and D exhibited shorter times to first bowel sounds,first defecation,and first flatus compared to Group A(P＜0.05),with Group D showing the shor-test durations(P＜0.05).Post-treatment,all groups demonstrated increased levels of CD3+,CD4+and CD4+/CD8+(P＜0.05),but Groups B,C,and D had higher levels than Group A(P＜0.05),with Group D leading(P＜0.05).Inflammatory markers IL-6,IL-10,and TNF-a decreased across all groups(P＜0.05),with Groups B,C,and D showing lower levels than Group A(P＜0.05),and Group D exhibiting the lowest levels(P＜0.05).Group D also reported lower incidences of postoperative vomiting and abdominal distension compared to Group A(P＜0.05).Conclusion:The combination of Zusanli injection and abdominal acupoint application in patients after laparoscopic surgery facilitates gastrointestinal function recovery,bolsters immune function,alleviates inflamma-tory responses,and reduces postoperative complications.
laparoscopyZusanliacupoint applicationgastrointestinal functionimmune functioninflam-matory state
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