慢性萎缩性胃炎"炎-癌"转化机制及治疗的研究进展
Research progress of the mechanism and treatment of"inflammation-cancer"transition of chronic atrophic gastritis
栾景祥 1王欣茹 1孙怡清 1刘维明2
作者信息
- 1. 山东中医药大学第一临床医学院(济南,250014)
- 2. 中国中医科学院广安门医院济南医院 济南市中医医院脾胃肝胆病科
- 折叠
摘要
"炎-癌"转化是近年来的研究热点,其干预和阻断对于预防炎症向癌症的进展至关重要.慢性萎缩性胃炎(chronic atrophic gastritis,CAG)作为消化系统的常见疾病,是胃癌发生的潜在转折点,通常被视为癌前状态.CAG病情具有易反复、病程较长且难以根治的特点,目前临床上缺乏针对该病的特异性治疗.本文将主要从中西医方面讨论CAG"炎-癌"转化的机制,并综述当前的治疗方案,旨在为临床治疗CAG并阻断其向胃癌的转化提供参考.
Abstract
In recent years,the"inflammation-cancer"transition has emerged as a significant research focus.Intervening in and blocking this process is a crucial measure to prevent the progression of inflammation to cancer.Chronic atrophic gastritis(CAG),a prevalent digestive system disorder,is recognized as a pivotal stage in the de-velopment of gastric cancer and is often regarded as a precancerous condition.CAG is characterized by frequent re-currence,a long course,and challenges in achieving a definitive cure,with no specific therapeutic interventions currently available in clinical practice.This article mainly discusses the mechanisms underlying the"inflammation-cancer"transition in CAG from both traditional Chinese and Western medicine perspectives,and summarizes the current treatment options in both fields,aiming to offering valuable insights for the clinical management of CAG and the prevention of its progression to gastric cancer.
关键词
慢性萎缩性胃炎/"炎-癌"转化/胃癌/幽门螺杆菌/细胞焦亡Key words
chronic atrophic gastritis/"inflammation-cancer"transition/gastric cancer/Helicobacter pylori/pyroptosis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据