Efficacy of Xuelian Yishen Decoction and Western Medicine in Spleen and Kidney Qi Deficiency Type Diabetes Nephropathy and the Effects on Oxidative Stress and Podocyte Damage
Objective:To investigate the efficacy of Xuelian yishen decoction and western medicine in spleen and kidney qi deficiency type diabetes nephropathy(SKQDDN)and the effects on oxidative stress and podocyte damage.Methods:92 SKQDDN pa-tients were collected and divided into the control group(CG)and the observation group(OG)equally.CG was intervened with west-ern medicine and OG was intervened with Xuelian yishen decoction additionally.The efficacy,24 h urine protein,24 h urine mi-croalbumin,traditional Chinese medicine syndrome score(TCMSS),oxidative stress indices,podocyte damage and adverse reaction of the two groups were compared.Results:Total efficacy of OG was higher than that of CG(93.5%vs 78.3%,P<0.05).After treatment,levels of 24 h urinary protein,24 h urinary microalbumin,TCMSS,malondialdehyde(MDA),and podocyte damage indi-ces of urinary nephrin and podocin protein in OG were lower than those in CG(P<0.05).Levels of oxidative stress indices of gluta-thione peroxidase(GSH-Px)and superoxide dismutase(SOD)in OG were higher than those in CG(P<0.05).There was no sig-nificant difference in adverse reactions between the two groups(P>0.05).Conclusion:Xuelian yishen decoction combined with western medicine has obvious efficacy,which can improve symptoms and reduce urinary protein in SKQDDN patients.And the mecha-nism may be related to alleviating oxidative stress and podocyte damage.
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