Objective:To investigate the levels of serum homocysteine(Hey)and vascular cell adhesion molecule-1(VCAM-1)in patients with renal secondary hyperparathyroidism(SHPT)and their correlation with cognitive function.Methods:A total of 113 SHPT patients with mild cognitive impairment who were admitted to our hospital from January 2020 to December 2021 were selected as the research subjects,and 110 patients without cognitive impairment during the same period were selected as the control group,Serum Hey and VCAM-1 levels were detected respectively.The diagnostic value of serum Hey and VCAM-1 on cognitive dysfunction in SHPT patients was analyzed by ROC curve,and the risk factors affecting cognitive dysfunction in SHPT patients were analyzed by Logistic multivariate regression.Results:Compared with the normal cognitive function group,the hemodialysis ratio,ser-um iPTH,Scr,serum phosphorus,serum calcium,Hey,VC AM-1 levels in the cognitive dysfunction group were significantly in-creased,and the MoCA score was significantly decreased(P＜0.05).The area under the curve(AUC)of serum Hey,VCAM-1 and combined diagnosis of cognitive dysfunction in patients with SHPT were 0.828,0.850 and 0.914,respectively;Dialysis mode,serum iPTH,years of education,Hey and VCAM-1 were risk factors for cognitive dysfunction in patients with SHPT(P＜0.05).Conclusion:Serum Hey and VCAM-1 levels are elevated in patients with renal secondary hyperparathyroidism,which are related to cognitive function and are independent risk factors for cognitive dysfunction.
万方数据
维普
