Risk Factors of Sarcopenia and its Correlation with Prognosis in Maintenance Hemodialysis Patients
Objective:To explore the incidence of sarcopenia and related risk factors of sarcopenia in maintenance hemodi-alysis(MHD)patients.and analyze its relationship with the prognosis.Methods:A total of 270 stable MHD patients were enrolled in the study.According to the diagnostic criteria established by the Asia Working Group for Sarcopenia(2019 Consensus Update on Sar-copenia Diagnosis and Treatment),the incidence of sarcopenia in patients was examined by measuring handgrip strength,walking speed and skeletal muscle mass of the limbs using bioelectrical impedance analysis.A multivariate Logistic regression analysis was performed on the influencing factors of sarcopenia.All patients were followed up for 12 months to observe the prognosis including fall,hospitalization and death from any cause.Results:Among 270 hemodialysis patients,the incidence of sarcopenia was 39.63%(107 cases).The age in sarcopenia group were bigger than these in the non-sarcopenia group.Diastolic blood pressure,gait speed,handgrip strength and appendicular skeletal muscle mass index in sarcopenia group were lesser than these in the non-sarcopenia group(P<0.05),and there was no statistically significant difference in the prevalence of diabetes mellitus and hypertension between the two groups(P>0.05).Serum creatinine,blood urea nitrogen,albumin and total iron binding capacity were lesser and C-reac-tive protein(CRP),serum ferritin and transferring saturation were higher in the sarcopenia group than these in the non-sarcopenia group(P<0.05).Multivariate logistic regression analysis showed that CRP,Age and total iron binding capacity were independent risk factors for sarcopenia.The incidence of fall ang readmission rate(16.82%and 54.21%)in the sarcopenia group during follow-up were higher than those(8.59%and31.90%)in the non-sarcopenia group(P<0.05).Conclusion:MHD patients experi-ence a relatively high incidence rate of sarcopenia.Age,inflammation and total iron binding capacity are the influencing factors of Sarcopenia in MHD patients.
NETL
NSTL
万方数据
