Effects of Baseline Peritoneal Membrane Transport Characteristics on Peritoneal Protein Clearance,Survival and the Incidence of Peritonitis in Continuous Ambulatory Peritoneal Dialysis Patients
Objective:To investigate the effect of baseline peritoneal transport characteristics on peritoneal protein loss,in-cidence of peritonitis and outcomes in continuous ambulatory peritoneal dialysis(CAPD)patients.Methods:91 patients who received regular CAPD for more than one year in our hospital from January 2014 to January 2021 were retrospectively analyzed.According to the results of the first peritoneal equilibration test(PET),patients were divided into four groups:high transport group(H),high aver-age transport group(HA),low average transport group(LA)and low transport group(L).The peritoneal protein clearance(PrC)a-mong the four groups were compared.The relationship between different primary diseases of ESRD and baseline peritoneal transport characteristics were also analyzed.Kaplan-Meier survival curves were used to analyze the survival of patients in the HT group(H and HA)and LT group(LA and L).Results:There were significant differences in PrC levels among these four groups.The level of PrC in the H group was significantly higher than that in HA group,LA group and L group,(P<0.05),while the level of serum al-bumin was significantly lower than that in other three groups.Baseline peritoneal transport characteristics were mostly HA and H in patients with diabetic nephropathy,while the LA and HA were the primary transport characteristics in patients with chronic glomerulo-nephritis.The in HT group was higher than that in LT group,There were no significant differences in the incidence of peritonitis and survival rate between HT group and LT group(P>0.05).Conclusion:Different primary diseases of ESRD effects the baseline peri-toneal transport characteristics of CAPD patients.Patients with high peritoneal transport are often accompanied by high PrC levels and low serum albumin levels,while peritoneal transport characteristics have no significant impact on the incidence of peritonitis as well as survival rate of CAPD patients.
Peritoneal equilibration testPeritoneal membrane transport characteristicsContinuous ambulatory perito-neal dialysisPeritoneal protein clearance
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