Clinical Prognostic Analysis of Prophylactic Anticoagulant Use in Patients with Primary Membranous Nephropathy with Different Serum Albumin Levels
Objective:To investigate whether there is a difference in clinical prognosis after prophylactic use of anticoagu-lants in patients with primary membranous nephropathy with different albumin levels,and to provide a reference for the prophylactic use of anticoagulants in primary membranous nephropathy.Methods:The clinical and pathological data of patients with primary mem-branous nephropathy(PMN)diagnosed by renal biopsy puncture from 1 January 2015 to 31 December 2021 in the Department of Nephrology,Shaanxi Provincial Hospital of Traditional Chinese Medicine were retrospectively included,including general information,clinical data,laboratory test indexes,etc.Ninety-eight patients who qualified for the study were evaluated and divided into low albu-min group(L1 group,serum albumin<25 g/L),medium albumin group(M1 group,serum albumin 25～32 g/L),and high albu-min group(H1 group,serum albumin>32 g/L)according to different serum albumin levels.With a median follow-up of 63 months,baseline information,clinical outcomes,and predictors of clinical outcomes were statistically analyzed for the three groups of patients on prophylactic anticoagulation.Results:A total of 98 patients meeting the study criteria were enrolled,42 in the L1 group,31 in the M1 group,and 25 in the H1 group,of which 4(9.5%),9(29.05%),and 11(44.05%)in the L1,M1,and H1 groups,respectively,achieved complete remission,25(59.5%),23(74.2%),and20(80.0%)achieved partial remission,and 21(50.0%),17(54.8%),and 21(84.0%)achieved hematuria remission.The difference between the three groups in complete and partial remission was statistically significant(P<0.05).After log-rank test,it was found that the differences between the three groups were statistically significant in the cumulative remission rate of complete remission(P =0.008)and the cumulative rate of he-maturia remission(P =0.008),and the difference was not statistically significant in the cumulative remission rate of partial remission(P =0.276).On multivariate Cox regression analysis,albumin level was positively associated with complete remission in PMN pa-tients(95%CI 1.579～18.882,P<0.05).Conclusion:Different serum albumin levels in patients with primary membranous ne-phropathy on prophylactic anticoagulation had different clinical outcomes,and different serum albumin levels were independent predic-tors of clinical outcome in patients with primary membranous nephropathy on prophylactic anticoagulation.
NETL
NSTL
万方数据
维普
