Establishment of a Mouse Model of Acute Kidney Injury Induced by Nuclear Radiation and Preliminary Study on the Mechanism of Injury
Objective:To establish a mouse model of acute kidney injury induced by nuclear radiation,and to explore its pathogenesis by Metabonomics.Methods:Eighteen C57 mice were divided into control group and model group.The model group was irradiated with 15Gy.The samples were taken at 6 h and 24 h after irradiation.Results:(1)Compared with the control group,the body weight decreased,renal index increased,blood urea nitrogen and urine microalbumin increased in the model group;(2)The re-nal cortex and medulla were poorly demarcated and the renal tubules were dilated;(3)Metabolomics has identified a variety of differ-ent metabolites that are associated with pathways such as Ferroptosis and Glutathione metabolism.Conclusion:15Gy irradiation for 6 h and 24 h could induce AKI,and the metabolite changes associated with Ferroptosis were found.
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