The Relationship Between Serum IL-27,VASH-1 Levels and Disease Progression in Patients with Chronic Kidney Disease and Their Diagnostic Value
Objective:To investigate the relationship between the levels of serum interleukin-27(IL-27),vasohibin-1(VASH-1)and the progression of chronic kidney disease,and analyze their diagnostic value.Methods:A total of 280 patients with chronic kidney disease diagnosed and treated in our hospital from June 2021 to October 2022 were selected as the observation group,and 285 healthy volunteers in the same period were regarded as the control group.According to the standard of kidney disease,the pa-tients were divided into 66 cases in stage 1 group,74 cases in stage 2 group,52 cases in stage 3 group,50 cases in stage 4 group,and 38 cases in stage 5 group.To compare serum IL-27 and VASH-1 levels in patients with chronic kidney disease(CKD)and to analyze the correlation between serum IL-27 and VASH-1 levels and both with blood creatinine(Scr),glomerular filtration rate(e-GFR),and the stage of CKD;Logistic regression analysis was conducted on the factors affecting chronic kidney disease;the di-agnostic value of serum IL-27 and VASH-1 levels in chronic kidney disease was analyzed by ROC curve.Results:Compared with the control group,the levels of IL-27,VASH-1 and Scr in serum of patients with chronic kidney disease in stage 1 group,stage 2 group,stage 3 group,stage 4 group and 5 stage group were obviously higher(P＜0.05),and e-GFR was obviously lower(P＜0.05).Serum IL-27 and VASH-1 were positively correlated with Scr levels in patients with chronic kidney disease(r=0.672,0.684,P＜0.05),and negatively correlated with e-GFR(r=-0.691,-0.679,P＜0.05),positively correlated with the stages of chronic kidney disease(r=0.668,0.659,P＜0.05),IL-27 was positively correlated with VASH-1(r=0.696,P＜0.05).BUN,Cys C,IL-27 and VASH-1 were risk factors for chronic kidney disease(P＜0.05).The area under the curve(AUC)of serum IL-27 combined with VASH-1 in the diagnosis of chronic kidney disease was 0.943,which was better than their respective diagnosis alone(Zcombination-IL-27=1.940,P=0.024;Zcombination-VASH-1=2.633,P=0.010).The AUC of serum IL-27 combined with VASH-1 in the diagnosis of chronic kidney disease stage 1 was 0.914,which was better than their respective diagnosis alone(Zcombination-IL-27=1.717,P=0.043;Zcombination-VASH-1=2.557,P=0.005).Conclusion:The levels of serum IL-27 and VASH-1 in patients with chronic kidney disease are elevated,they are related to the progress of chronic kidney disease and have certain diag-nostic value for chronic kidney disease.
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