Objective:To evaluate the factors and traditional Chinese medicine(TCM)syndrome in hemodialysis-associat-ed sarcopenia patients using a single center study.Methods:Underlying the criteria introduced by the Asian Working Group in Sar-copenia in 2019,169 patients were enrolled who were divided into sarcopenia group and non-sarcopenia group.We analyzed muscle mass,muscle strength,physical function within two groups,as well as that factors for sarcopenia.Based on the TCM diagnosis infor-mation in 119 patients with sarcopenia or possible sarcopenia,the relationship between TCM syndrome and related indicators of sar-copenia syndrome is summarized.Results:(1)Among169 patients,34(20.1%)were sarcopenia and 85(50.3%)were possible sarcopenia.Logistic multivariate regression analysis showed that advanced age(OR=1.305,95%CI:1.159～1.471,P<0.001)and male(OR=5.473,95%CI:1.02～29.367,P=0.047)were risk factors for sarcopenia.Higher BMI(OR=0.385,95%CI:0.255～0.581,P<0.001)was a protective factor for sarcopenia.(2)Through factor analysis,11 common factors were extracted.Combined with cluster analysis and TCM syndrome differentiation,the TCM syndromes of patients with sarcopenia and possible sar-copenia were 50 cases(42.01%)of liver and kidney deficiency and dampness stasis syndrome,49 cases(41.18%)of spleen and kidney Qi deficiency syndrome,and 20 cases(16.81%)of Qi and Yin deficiency syndrome.(3)In a study comparing gait speed and appendicular skeletal muscle mass index among patients with different TCM syndromes,statistically significant differences were observed(P<0.05).Specifically,patients with spleen and kidney Qi deficiency syndrome had lower appendicular skeletal muscle mass index compared to those with Qi and Yin deficiency syndrome and liver and kidney deficiency and dampness stasis syndrome(P<0.05).Their gait speed was also slower than that of Qi and Yin deficiency syndrome(P<0.05).However,there were no sta-tistically significant differences in handgrip strength among the three groups of patients(P＞0.05).Conclusion:(1)The prevalence of dialysis-related sarcopenia was 20.1%.The risk factors in sarcopenia includes seniors and male,while the BMI as the protective factor in this disease.(2)The risk factors in sarcopenia includes seniors and male,while the BMI as the protective factor in this dis-ease.In dialysis-associated sarcopenia,three TCM syndromes were common,including liver and kidney deficiency and dampness and blood stasis syndrome,spleen and kidney Qi deficiency syndrome,Qi and Yin deficiency syndrome.The indexes of muscle mass and physical function were lower in patients with spleen-kidney Qi deficiency syndrome.
SarcopeniaHemodialysisInfluencing factorsTCM syndrome typeClinical research
NETL
NSTL
万方数据
