Correlation Between Serum Interleukin-6 and Urine Protein Levels in Patients with Primary Membranous Nephropathy and Relationship with Traditional Chinese Medicine Syndrome Patterns
Objective:To investigate the relationship between cytokines and urine protein levels,Traditional Chinese Medi-cine syndrome patterns and prognosis in primary membranous nephropathy(PMN).Methods:This is a prospective study.Eighty-one patients with PMN confirmed by renal biopsy at China-Japan Friendship Hospital from June 2021 to March 2022 were included in the disease group and another 22 cases were included in the healthy population as a control group.Serum interleukin-6 and interleu-kin-17 levels were measured in all patients before treatment,and the disease group was subjected to Traditional Chinese Medicine syndromes classification and long-term follow-up.SPSS 26.0 was used for data analysis.Results:Serum interleukin-6 levels were significantly higher in the disease group than in the control group(P<0.001)and there was a correlation between interleukin-6 lev-els and urine protein.The two groups did not show significant differences in serum interleukin-17 levels.In terms of Traditional Chi-nese Medicine syndrome patterns,the elevated interleukin-6 group was more common in the Spleen-kidney Yang deficiency syn-drome and Blood stasis syndrome,while the normal interleukin-6 group was more common in the Qi deficiency syndrome.Prognosti-cally,the interleukin-6 elevated group had a lower rate of clinical remission and a longer time to achieve median remission compared to the interleukin-6 normal group.Conclusion:PMN patients had a micro-inflammatory state.Serum interleukin-6 levels correla-ted with urine protein levels,Traditional Chinese Medicine syndrome patterns,and prognosis.
Membranous nephropathyProteinuriaInterleukin-6Traditional Chinese Medicine syndrome patterns
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