首页|基于fMRI研究经筋疗法对健康人脑网络拓扑结构的影响

基于fMRI研究经筋疗法对健康人脑网络拓扑结构的影响

Effects of meridian sinew therapy on functional brain networks in healthy individuals by fMRI

扫码查看
原文链接
  • 国家科技期刊平台
  • NETL
  • NSTL
  • 维普
  • 万方数据
目的:使用静息态BOLD-fMRI结合图论方法,分析健康志愿者经筋治疗前后功能脑网络的拓扑结构,以揭示经筋疗法对脑神经网络的调控机制.方法:招募41例健康志愿者,随机分为理筋伴针刺组21例和单纯理筋组20例,采集治疗前后简单反应时间测试、舒尔特方格测试、颅脑MRI 3D-T1WI及BOLD数据.使用GRETNA软件构建功能脑网络、计算拓扑参数,并行治疗前后组内及组间比较.结果:治疗后2组反应力和注意力均显著提高;理筋伴针刺组的全局效率(Eglob)和小世界属性(σ)提高,聚类系数(Cp)和特征路径长度(Lp)降低,而理筋组仅Eglob提高和Lp降低;理筋伴针刺组发现一神经回路连接强度减弱,包括86条连边和73个节点.相关性分析示Eglob、标准化聚类系数(γ)和σ分别与舒尔特方格时间呈负相关,而Lp与舒尔特方格时间呈正相关.结论:经筋治疗能重塑功能脑网络、优化其信息处理模式,进而增强志愿者的反应力和注意力,这种重塑作用可能是其治未病疗效的作用基础.而针刺松解筋结点作为经筋疗法的重要组成部分,对功能网络的重塑有重要作用.
Objective:To analyze the topology of functional brain networks in healthy volunteers before and after meridian sinew therapy using BOLD-fMRI combined with graph theory methods to reveal the modulation mechanisms of brain neural networks by meridian sinew therapy.Methods:Forty-one healthy volunteers were recruited and randomly assigned to the myofascial-release with acupuncture group(21 cases)and the myofascial-release group(20 cases).Simple reaction time test,Schulte grid test,cranial MRI 3D-T1WI and BOLD data were collected before and after treatment.GRETNA software was used to construct functional brain networks and calculate topological parameters for intra-group and inter-group comparisons before and after treatment.Results:After treatment,the two groups showed an increase in responsiveness and attention.The myofascial-release with acupuncture group showed an increase in global efficiency(Eglob)and small-worldness(σ),and a decrease in clustering coefficients(Cp)and characteristic path length(Lp).The myofascial-release group showed an increase in Eglob and a decrease in Lp.The myofascial-release with acupuncture group also showed a reduced strength of one-neural circuit connections,including 86 edges and 73 nodes.Correlation analysis showed that Eglob,the normalized clustering coefficient(γ)and σ were negatively correlated with Schulte grid time,while Lp was positively correlated with Schulte grid time.Conclusions:Meridian sinew therapy can significantly reshape functional brain networks and optimize their information processing patterns,thereby enhancing volunteers'responsiveness and attention.Acupuncture,as an important component of meridian sinew therapy,can play a crucial role in the structural remodeling of functional networks,which may be the basis for its disease prevention role.

Traditional Chinese medicineMeridian sinew theoryAcupunctureFunctional magnetic resonance imagingGraph theoryBrain functional network

张耿标、郑鸿毅、庄佳燕、吴碧霞、李伟佳、吴京铧、郑文斌

展开 >

汕头大学医学院第二附属医院医学影像科,广东 汕头 515041

汕头大学医学院,广东 汕头 515041

北京筋柔中医研究院,北京 100000

广东省汕头市龙湖区筋柔中医技术研究院,广东 汕头 515000

展开 >

中医 经筋理论 针刺 功能磁共振成象 图论 脑功能网络

省科技创新战略专项市县科技创新支撑(大专项+任务清单)项目广东省"新医科"教指委教学改革项目(2023)广东省基础与应用基础研究基金企业联合基金

STKJ20230421292021A1515220112

2024

10.3969/j.issn.1672-0512.2024.01.010

中国中西医结合影像学杂志
中国中西医结合学会,山东中医药大学附属医院

中国中西医结合影像学杂志

CSTPCD
影响因子：0.857
ISSN：1672-0512
年,卷(期)：2024.22(1)
  • 10