Study of resting-state fMRI based on ReHo and fALFF in patients with motor dysfunction after dominant and non-dominant hemispheres basal ganglia cerebral infarction
Objective:To investigate the local spontaneous activity changes of regional homogeneity(ReHo)and fraction amplitude of low-frequency fluctuation(fALFF)by resting-state fMRI(rs-fMRI)in patients with motor dysfunction after dominant and non-dominant hemispheres basal ganglia cerebral infarction.Methods:Rs-fMRI was performed on 20 patients with motor dysfunction after basal ganglia cerebral infarction who were divided into dominant hemisphere cerebral infarction group(DHCI group,11 cases)and non-dominant hemisphere cerebral infarction group(NDHCI group,9 cases)according to the lesion location.At the same time,18 healthy controls(the control group)underwent rs-fMRI.Data were processed and analyzed using the SPM12 and DPARSF toolboxs based on MATLAB,and the two-sample t-test(voxel level P<0.01,cluster level P<0.05,corrected by GRF)was used to compare the ReHo and fALFF brain maps between groups.The ReHo and fALFF values were extracted from the differential brain regions.Results:Compared with the control group,ReHo value of left triangular inferior frontal gyrus increased and the fALFF value of the left cingulate gyrus white matter decreased significantly in DHCI group(both P<0.05).Compared with the control group,the brain areas with increased ReHo value in NDHCI group included the left middle frontal gyrus(t=6.01,P<0.05),with decreased ReHo value included the left median cingulate and paracingulate gyrus(t=-6.02,P<0.05)and the right superior occipital gyrus(t=-5.25,P<0.05);and the brain areas with increased fALFF value included the right orbital inferior frontal gyrus(t=5.01,P<0.05)and left middle occipital gyrus(t=4.74,P<0.05),with decreased fALFF value included the right median cingulate and paracingulate gyrus(t=-5.58,P<0.05).Compared with NDHCI group,the brain areas with increased ReHo value in DHCI group included left cerebellum(t=4.51,P<0.05),with increased fALFF value included left triangular inferior frontal gyrus(t=5.29,P<0.05),left lingual gyrus(t=5.63,P<0.05),left middle frontal gyrus(t=6.72,P<0.05).Conclusions:In the resting state,neuronal activities in bilateral cortical motor,sensory and cognitive areas were changed after basal ganglia cerebral infarction in DHCI and NDHCI patients compared with healthy controls.Meanwhile,DHCI can show faster compensatory activation and enhance neuronal activity compared with NDHCI,which may contribute to further understanding of the regional neuroimaging differences in patients with motor dysfunction after basal ganglia cerebral infarction between different hemispheres.
Basal ganglia cerebral infarctionMotor dysfunctionRegional homogeneityFraction amplitude of low-frequency fluctuationResting-state functional magnetic resonance imaging
国家科技期刊平台
NSTL
维普
万方数据
